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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise

http://hdl.handle.net/2237/00031585
ae36417c-fb82-45bc-bcd3-677e619a9186
名前 / ファイル ライセンス アクション
Oshino_manuscript_20200310_repository.pdf Oshino_manuscript_20200310_repository (147.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-12
タイトル
タイトル Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise
著者 Negishi-Oshino, Reina

× Negishi-Oshino, Reina

WEKO 96559

Negishi-Oshino, Reina

Search repository
Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 96560

Ohgami, Nobutaka

Search repository
He, Tingchao

× He, Tingchao

WEKO 96561

He, Tingchao

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Li, Xiang

× Li, Xiang

WEKO 96562

Li, Xiang

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Kato, Masashi

× Kato, Masashi

WEKO 96563

Kato, Masashi

Search repository
Kobayashi, Masayoshi

× Kobayashi, Masayoshi

WEKO 96564

Kobayashi, Masayoshi

Search repository
Gu, Yishuo

× Gu, Yishuo

WEKO 96565

Gu, Yishuo

Search repository
Komuro, Kanako

× Komuro, Kanako

WEKO 96566

Komuro, Kanako

Search repository
Angelidis, Charalampos E.

× Angelidis, Charalampos E.

WEKO 96567

Angelidis, Charalampos E.

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 96568

Kato, Masashi

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Archives of Toxicology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00204-019-02587-3”.
キーワード
主題Scheme Other
主題 HSP70
キーワード
主題Scheme Other
主題 Low-frequency noise
キーワード
主題Scheme Other
主題 Otoconial membrane
キーワード
主題Scheme Other
主題 cVEMP
キーワード
主題Scheme Other
主題 Balance
抄録
内容記述 A previous study showed that people living in urban areas are generally exposed to low-frequency noise (LFN) with frequencies below 100 Hz and sound levels of 60–110 dB in daily and occupational environments. Exposure to LFN has been shown to affect balance in humans and mice. However, there is no information about prevention of LFN-mediated imbalance because of a lack of information about the target region based on health risk assessment of LFN exposure. Here, we show that acute exposure to LFN at 100 Hz, 95 dB, but not at 85 dB or 90 dB, for only 1 h caused imbalance in mice. The exposed mice also had decreased cervical vestibular-evoked myogenic potential (cVEMP) with impaired activity of vestibular hair cells. Since imbalance in the exposed mice was irreversible, morphological damage in the vestibules of the exposed mice was further examined. The exposed mice had breakage of the otoconial membrane in the vestibule. LFN-mediated imbalance and breakage of the otoconial membrane in mice were rescued by overexpression of a stress-reactive molecular chaperone, heat shock protein 70 (Hsp70), which has been shown to be induced by exposure of mice to 12 h per day of LFN at 95 dB for 5 days. Taken together, the results of this study demonstrate that acute exposure to LFN at 100 Hz, 95 dB for only 1 h caused irreversible imbalance in mice with structural damage of the otoconial membrane as the target region for LFN-mediated imbalance, which can be rescued by Hsp70.
内容記述タイプ Abstract
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00204-019-02587-3
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0340-5761
書誌情報 Archives of Toxicology

巻 93, 号 11, p. 3219-3228, 発行日 2019-11
著者版フラグ
値 author
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