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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise

http://hdl.handle.net/2237/00031585
http://hdl.handle.net/2237/00031585
ae36417c-fb82-45bc-bcd3-677e619a9186
名前 / ファイル ライセンス アクション
Oshino_manuscript_20200310_repository.pdf Oshino_manuscript_20200310_repository (147.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-12
タイトル
タイトル Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise
言語 en
著者 Negishi-Oshino, Reina

× Negishi-Oshino, Reina

WEKO 96559

en Negishi-Oshino, Reina

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Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 96560

en Ohgami, Nobutaka

Search repository
He, Tingchao

× He, Tingchao

WEKO 96561

en He, Tingchao

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Li, Xiang

× Li, Xiang

WEKO 96562

en Li, Xiang

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Kato, Masashi

× Kato, Masashi

WEKO 96563

en Kato, Masashi

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Kobayashi, Masayoshi

× Kobayashi, Masayoshi

WEKO 96564

en Kobayashi, Masayoshi

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Gu, Yishuo

× Gu, Yishuo

WEKO 96565

en Gu, Yishuo

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Komuro, Kanako

× Komuro, Kanako

WEKO 96566

en Komuro, Kanako

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Angelidis, Charalampos E.

× Angelidis, Charalampos E.

WEKO 96567

en Angelidis, Charalampos E.

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Kato, Masashi

× Kato, Masashi

WEKO 96568

en Kato, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Archives of Toxicology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00204-019-02587-3”.
キーワード
主題Scheme Other
主題 HSP70
キーワード
主題Scheme Other
主題 Low-frequency noise
キーワード
主題Scheme Other
主題 Otoconial membrane
キーワード
主題Scheme Other
主題 cVEMP
キーワード
主題Scheme Other
主題 Balance
抄録
内容記述 A previous study showed that people living in urban areas are generally exposed to low-frequency noise (LFN) with frequencies below 100 Hz and sound levels of 60–110 dB in daily and occupational environments. Exposure to LFN has been shown to affect balance in humans and mice. However, there is no information about prevention of LFN-mediated imbalance because of a lack of information about the target region based on health risk assessment of LFN exposure. Here, we show that acute exposure to LFN at 100 Hz, 95 dB, but not at 85 dB or 90 dB, for only 1 h caused imbalance in mice. The exposed mice also had decreased cervical vestibular-evoked myogenic potential (cVEMP) with impaired activity of vestibular hair cells. Since imbalance in the exposed mice was irreversible, morphological damage in the vestibules of the exposed mice was further examined. The exposed mice had breakage of the otoconial membrane in the vestibule. LFN-mediated imbalance and breakage of the otoconial membrane in mice were rescued by overexpression of a stress-reactive molecular chaperone, heat shock protein 70 (Hsp70), which has been shown to be induced by exposure of mice to 12 h per day of LFN at 95 dB for 5 days. Taken together, the results of this study demonstrate that acute exposure to LFN at 100 Hz, 95 dB for only 1 h caused irreversible imbalance in mice with structural damage of the otoconial membrane as the target region for LFN-mediated imbalance, which can be rescued by Hsp70.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00204-019-02587-3
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0340-5761
書誌情報 en : Archives of Toxicology

巻 93, 号 11, p. 3219-3228, 発行日 2019-11
著者版フラグ
値 author
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