{"created":"2021-03-01T06:37:35.213343+00:00","id":29399,"links":{},"metadata":{"_buckets":{"deposit":"ddee1a09-63c1-4c98-85bc-42d1a5ec931c"},"_deposit":{"id":"29399","owners":[],"pid":{"revision_id":0,"type":"depid","value":"29399"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00029399","sets":["499:500:501"]},"author_link":["96559","96560","96561","96562","96563","96564","96565","96566","96567","96568"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"3228","bibliographicPageStart":"3219","bibliographicVolumeNumber":"93","bibliographic_titles":[{"bibliographic_title":"Archives of Toxicology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A previous study showed that people living in urban areas are generally exposed to low-frequency noise (LFN) with frequencies below 100 Hz and sound levels of 60–110 dB in daily and occupational environments. Exposure to LFN has been shown to affect balance in humans and mice. However, there is no information about prevention of LFN-mediated imbalance because of a lack of information about the target region based on health risk assessment of LFN exposure. Here, we show that acute exposure to LFN at 100 Hz, 95 dB, but not at 85 dB or 90 dB, for only 1 h caused imbalance in mice. The exposed mice also had decreased cervical vestibular-evoked myogenic potential (cVEMP) with impaired activity of vestibular hair cells. Since imbalance in the exposed mice was irreversible, morphological damage in the vestibules of the exposed mice was further examined. The exposed mice had breakage of the otoconial membrane in the vestibule. LFN-mediated imbalance and breakage of the otoconial membrane in mice were rescued by overexpression of a stress-reactive molecular chaperone, heat shock protein 70 (Hsp70), which has been shown to be induced by exposure of mice to 12 h per day of LFN at 95 dB for 5 days. Taken together, the results of this study demonstrate that acute exposure to LFN at 100 Hz, 95 dB for only 1 h caused irreversible imbalance in mice with structural damage of the otoconial membrane as the target region for LFN-mediated imbalance, which can be rescued by Hsp70.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00204-019-02587-3","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is a post-peer-review, pre-copyedit version of an article published in [Archives of Toxicology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00204-019-02587-3”.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0340-5761","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Negishi-Oshino, Reina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohgami, Nobutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"He, Tingchao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Xiang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gu, Yishuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komuro, Kanako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Angelidis, Charalampos E.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"96568","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-01"}],"displaytype":"detail","filename":"Oshino_manuscript_20200310_repository.pdf","filesize":[{"value":"147.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Oshino_manuscript_20200310_repository","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/29399/files/Oshino_manuscript_20200310_repository.pdf"},"version_id":"a3ba10f1-3ae5-44a7-977a-98a750e4b1a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HSP70","subitem_subject_scheme":"Other"},{"subitem_subject":"Low-frequency noise","subitem_subject_scheme":"Other"},{"subitem_subject":"Otoconial membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"cVEMP","subitem_subject_scheme":"Other"},{"subitem_subject":"Balance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"29399","relation_version_is_last":true,"title":["Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:43:24.778035+00:00"}