{"created":"2021-03-01T06:38:20.905603+00:00","id":30077,"links":{},"metadata":{"_buckets":{"deposit":"a28e3e5d-bd05-42f2-89d7-3c393cba813e"},"_deposit":{"id":"30077","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30077"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030077","sets":["499:500:501"]},"author_link":["99204","99205","99206","99207","99208","99209","99210","99211","99212","99213","99214","99215","99216","99217"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"43","bibliographicPageStart":"eaav3937","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Science Immunology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The clinical efficacy of anti–PD-1 (programmed cell death–1) monoclonal antibody (mAb) against cancers with oncogenic driver gene mutations, which often harbor a low tumor mutation burden, is variable, suggesting different contributions of each driver mutation to immune responses. Here, we investigated the immunological phenotypes in the tumor microenvironment (TME) of epidermal growth factor receptor (EGFR)–mutated lung adenocarcinomas, for which anti–PD-1 mAb is largely ineffective. Whereas EGFR-mutated lung adenocarcinomas had a noninflamed TME, CD4^+ effector regulatory T cells, which are generally present in the inflamed TME, showed high infiltration. The EGFR signal activated cJun/cJun N-terminal kinase and reduced interferon regulatory factor–1; the former increased CCL22, which recruits CD4^+ regulatory T cells, and the latter decreased CXCL10 and CCL5, which induce CD8^+ T cell infiltration. The EGFR inhibitor erlotinib decreased CD4^+ effector regulatory T cells infiltration in the TME and in combination with anti–PD-1 mAb showed better antitumor effects than either treatment alone. Our results suggest that EGFR inhibitors when used in conjunction with anti–PD-1 mAb could increase the efficacy of immunotherapy in lung adenocarcinomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1126/sciimmunol.aav3937","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science Immunology] on [v.5, n.43, Jan 2020], DOI: [10.1126/sciimmunol.aav3937].”","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"2470-9468","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugiyama, Eri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togashi, Yosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinya, Sayoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tada, Yasuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tane, Kenta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Eiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Genichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goto, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shintani, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, Meinoshin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuboi, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikawa, Hiroyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99217","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-28"}],"displaytype":"detail","filename":"200525_Science_immunology_EGFRmt.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"200525_Science_immunology_EGFRmt","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30077/files/200525_Science_immunology_EGFRmt.pdf"},"version_id":"e4796ba6-d71c-40b8-8a5e-ae5c5886e976"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-28"},"publish_date":"2020-05-28","publish_status":"0","recid":"30077","relation_version_is_last":true,"title":["Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:23:16.861710+00:00"}