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A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia
https://doi.org/10.18999/nagjms.82.2.345
https://doi.org/10.18999/nagjms.82.2.345689bd558-29bf-43ec-82fd-c5f9ef30cb83
名前 / ファイル | ライセンス | アクション |
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18_Tachi.pdf (3.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-06-01 | |||||
タイトル | ||||||
タイトル | A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia | |||||
言語 | en | |||||
著者 |
Tachi, Asuka
× Tachi, Asuka× Moriyama, Yoshinori× Tsuda, Hiroyuki× Miki, Rika× Ushida, Takafumi× Miura, Mayo× Ito, Yumiko× Imai, Kenji× Nakano-Kobayashi, Tomoko× Hayakawa, Masahiro× Kikkawa, Fumitaka× Kotani, Tomomi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pulmonary hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liquid chromatography–tandem mass spectrometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Complement and coagulation cascade | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Congenital diaphragmatic hernia (CDH) is a congenital anomaly characterized by a defect in the diaphragm. Despite the recent improvements in its treatment, CDH is associated with a high rate of neonatal mortality, which is often related to pulmonary hypoplasia (PH) as well as pulmonary hypertension. A better understanding of the underlying pathological mechanisms of PH in CDH could help establish a new treatment to improve its prognosis. In this study, we investigated serum biological profiles in neonates with CDH. For comprehensive investigation, umbilical cord serum samples were collected from isolated CDH cases (n = 4) and matched healthy controls (n = 4). Samples were analyzed using liquid chromatography–tandem mass spectrometry. A total of 697 proteins were detected; of them, 98 were identified as differentially expressed proteins. Among these differentially expressed proteins, complement C1q subcomponent showed the largest fold change, followed by complement C5. In the pathway enrichment analysis, the complement and coagulation cascades expressed the most significant enrichment (p = 2.4 × 10^−26). Thus, the complement pathway might play some role in the pathophysiology of CDH. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The present study was supported by a research grant from JSPS KAKENHI (Grant Number: 15H02660). | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.82.2.345 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 82, 号 2, p. 345-354, 発行日 2020-05 |
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著者版フラグ | ||||||
値 | publisher |