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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(2)

A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia

https://doi.org/10.18999/nagjms.82.2.345
https://doi.org/10.18999/nagjms.82.2.345
689bd558-29bf-43ec-82fd-c5f9ef30cb83
名前 / ファイル ライセンス アクション
18_Tachi.pdf 18_Tachi.pdf (3.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-06-01
タイトル
タイトル A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia
著者 Tachi, Asuka

× Tachi, Asuka

WEKO 99397

Tachi, Asuka

Search repository
Moriyama, Yoshinori

× Moriyama, Yoshinori

WEKO 99398

Moriyama, Yoshinori

Search repository
Tsuda, Hiroyuki

× Tsuda, Hiroyuki

WEKO 99399

Tsuda, Hiroyuki

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Miki, Rika

× Miki, Rika

WEKO 99400

Miki, Rika

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Ushida, Takafumi

× Ushida, Takafumi

WEKO 99401

Ushida, Takafumi

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Miura, Mayo

× Miura, Mayo

WEKO 99402

Miura, Mayo

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Ito, Yumiko

× Ito, Yumiko

WEKO 99403

Ito, Yumiko

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Imai, Kenji

× Imai, Kenji

WEKO 99404

Imai, Kenji

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Nakano-Kobayashi, Tomoko

× Nakano-Kobayashi, Tomoko

WEKO 99405

Nakano-Kobayashi, Tomoko

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Hayakawa, Masahiro

× Hayakawa, Masahiro

WEKO 99406

Hayakawa, Masahiro

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Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 99407

Kikkawa, Fumitaka

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Kotani, Tomomi

× Kotani, Tomomi

WEKO 99408

Kotani, Tomomi

Search repository
キーワード
主題Scheme Other
主題 pulmonary hypertension
キーワード
主題Scheme Other
主題 Liquid chromatography–tandem mass spectrometry
キーワード
主題Scheme Other
主題 Complement and coagulation cascade
抄録
内容記述 Congenital diaphragmatic hernia (CDH) is a congenital anomaly characterized by a defect in the diaphragm. Despite the recent improvements in its treatment, CDH is associated with a high rate of neonatal mortality, which is often related to pulmonary hypoplasia (PH) as well as pulmonary hypertension. A better understanding of the underlying pathological mechanisms of PH in CDH could help establish a new treatment to improve its prognosis. In this study, we investigated serum biological profiles in neonates with CDH. For comprehensive investigation, umbilical cord serum samples were collected from isolated CDH cases (n = 4) and matched healthy controls (n = 4). Samples were analyzed using liquid chromatography–tandem mass spectrometry. A total of 697 proteins were detected; of them, 98 were identified as differentially expressed proteins. Among these differentially expressed proteins, complement C1q subcomponent showed the largest fold change, followed by complement C5. In the pathway enrichment analysis, the complement and coagulation cascades expressed the most significant enrichment (p = 2.4 × 10^−26). Thus, the complement pathway might play some role in the pathophysiology of CDH.
内容記述タイプ Abstract
内容記述
内容記述 The present study was supported by a research grant from JSPS KAKENHI (Grant Number: 15H02660).
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.2.345
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 2, p. 345-354, 発行日 2020-05
著者版フラグ
値 publisher
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