@article{oai:nagoya.repo.nii.ac.jp:00030166,
 author = {Hanatani, Maya and Yoshikawa, Nobuhisa and Yoshida, Kosuke and Tamauchi, Satoshi and Ikeda, Yoshiki and Nishino, Kimihiro and Niimi, Kaoru and Suzuki, Shiro and Kawai, Michiyasu and Kajiyama, Hiroaki and Kikkawa, Fumitaka},
 issue = {1},
 journal = {International Journal of Clinical Oncology},
 month = {Jan},
 note = {Background: Little is known about the effect of age on the prognosis of epithelial ovarian neoplasms. In the reproductive age, fertility-sparing surgery had been widely implemented. This study aimed to elucidate impact of age on the clinicopathologic characteristics and survival of epithelial ovarian neoplasms in the reproductive age. Methods: The clinical records of patients diagnosed as epithelial ovarian cancer or epithelial borderline ovarian tumor at the age of 40 years or younger at multiple institutions in the Tokai Ovarian Tumor Study Group were reviewed retrospectively. All patients were stratified into two age groups: group A (≤ 30 years) and group B (31–40 years). Univariate and multivariate analyses were performed to evaluate overall survival and disease-free survival. Results: A total of 583 patients (325 patients: cancer, 258 patients: borderline) were included. The median follow-up time was 62.0 months (range 1–270 months). Compared with group B, group A had a significantly higher rate of borderline tumor (66.7% vs. 32.7%, p < 0.001); stage I disease (85.9% vs. 70.4%, p < 0.001); mucinous type (69.2% vs. 35.6%, p < 0.001); conservative surgery (83.8% vs. 41.6%, p < 0.001); no adjuvant chemotherapy (67.2% vs. 44.7%, p < 0.001); and CA125 ≤ 35 U/mL (39.4% vs. 28.8%, p < 0.05). There was a significant difference in the overall survival (p = 0.0051) and the disease-free survival (p = 0.0039) between the two groups. Multivariate analysis revealed that the independent prognostic factors for the overall survival were age, stage, histology, and ascitic fluid cytology. Conclusion: In epithelial ovarian neoplasms, younger patients had a survival advantage over older patients., ファイル公開：2021/01/01},
 pages = {187--194},
 title = {Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age},
 volume = {25},
 year = {2020}
}