{"created":"2021-03-01T06:38:27.125662+00:00","id":30167,"links":{},"metadata":{"_buckets":{"deposit":"344e9779-062b-4de2-9f33-ae78d25c9f23"},"_deposit":{"id":"30167","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30167"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030167","sets":["499:500:501"]},"author_link":["99622","99623","99624","99625","99626","99627","99628","99629","99630","99631","99632","99633","99634"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"119","bibliographicPageStart":"112","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"International Journal of Hematology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II–IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II–IV acute GVHD (P = 0.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P = 0.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2021/01/01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12185-019-02739-2","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2”.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0925-5710","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamoshita, Sonoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koyama, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Julamanee, Jakrawadee","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okuno, Shingo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi, Erina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyao, Kotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goto, Tatsunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Yukiyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyamura, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terakura, Seitaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyoi, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"99634","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-01"}],"displaytype":"detail","filename":"Murata_Int_J_Hematol2020.pdf","filesize":[{"value":"354.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Murata_Int_J_Hematol2020","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30167/files/Murata_Int_J_Hematol2020.pdf"},"version_id":"b1059583-022c-4666-a2d4-6ee89280f07c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Graft-versus-host disease","subitem_subject_scheme":"Other"},{"subitem_subject":"ACAT1","subitem_subject_scheme":"Other"},{"subitem_subject":"Single nucleotide polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"Transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Donor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-12"},"publish_date":"2020-06-12","publish_status":"0","recid":"30167","relation_version_is_last":true,"title":["Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:23:22.895933+00:00"}