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A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule
http://hdl.handle.net/2237/00032521
http://hdl.handle.net/2237/00032521373efd9a-fdb7-4209-b2a5-19f2e7ffb93d
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-17 | |||||
タイトル | ||||||
タイトル | A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule | |||||
言語 | en | |||||
著者 |
Ohgami, Nobutaka
× Ohgami, Nobutaka× He, Tingchao× Oshino-Negishi, Reina× Gu, Yishuo× Li, Xiang× Kato, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Toxicology and Environmental Health, Part A on 05/04/2020, available online: http://www.tandfonline.com/10.1080/15287394.2020.1746945. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | low frequency noise | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | risk assessment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vestibule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | otoconial membrane | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | balance | |||||
抄録 | ||||||
内容記述 | Health risks attributed to low-frequency noise (LFN) exposure are a serious global issue. Therefore, the development of a method for a prevention based upon risk assessments for LFN is important. Previously in vivo exposure of mice to LFN at 100 Hz, 95 dB for 1 hr produced imbalance with breakage of the otoconial membrane, which covers hair cells as well as impaired activity of hair cells in the vestibule. However, methods for inhibition of LFN-mediated imbalance have not been developed. At present, there are no apparent techniques available with in vitro or ex vivo assessments to evaluate LFN-mediated imbalance by direct administration of preventive chemicals into the vestibule. Our findings demonstrated the usefulness of an explant culture of the utricle with a fluorescent styryl dye, FM1-43FX. In addition, examination of the morphology of the otoconial membrane with explant cultures of utricles was conducted to determine the risk of LFN. Ex vivo exposure of the utricle to LFN at 100 Hz, 95 dB for 1 hr induced breaks in the otoconial membrane as well as decreased uptake of FM1-43FX in hair cells. Taken together, the results of this study provide a novel technique for assessing the risk of LFN exposure using an ex vivo experiment. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2021/04/05 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Taylor & Francis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1080/15287394.2020.1746945 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1528-7394 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1087-2620 | |||||
書誌情報 |
en : Journal of Toxicology and Environmental Health, Part A 巻 83, 号 5, p. 215-218, 発行日 2020-04-05 |
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著者版フラグ | ||||||
値 | author |