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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule

http://hdl.handle.net/2237/00032521
http://hdl.handle.net/2237/00032521
373efd9a-fdb7-4209-b2a5-19f2e7ffb93d
名前 / ファイル ライセンス アクション
UTEH-2020-0106_R1_repository.pdf UTEH-2020-0106_R1_repository (4.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-07-17
タイトル
タイトル A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule
言語 en
著者 Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 100640

en Ohgami, Nobutaka

Search repository
He, Tingchao

× He, Tingchao

WEKO 100641

en He, Tingchao

Search repository
Oshino-Negishi, Reina

× Oshino-Negishi, Reina

WEKO 100642

en Oshino-Negishi, Reina

Search repository
Gu, Yishuo

× Gu, Yishuo

WEKO 100643

en Gu, Yishuo

Search repository
Li, Xiang

× Li, Xiang

WEKO 100644

en Li, Xiang

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 100645

en Kato, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Toxicology and Environmental Health, Part A on 05/04/2020, available online: http://www.tandfonline.com/10.1080/15287394.2020.1746945.
キーワード
主題Scheme Other
主題 low frequency noise
キーワード
主題Scheme Other
主題 risk assessment
キーワード
主題Scheme Other
主題 vestibule
キーワード
主題Scheme Other
主題 otoconial membrane
キーワード
主題Scheme Other
主題 balance
抄録
内容記述 Health risks attributed to low-frequency noise (LFN) exposure are a serious global issue. Therefore, the development of a method for a prevention based upon risk assessments for LFN is important. Previously in vivo exposure of mice to LFN at 100 Hz, 95 dB for 1 hr produced imbalance with breakage of the otoconial membrane, which covers hair cells as well as impaired activity of hair cells in the vestibule. However, methods for inhibition of LFN-mediated imbalance have not been developed. At present, there are no apparent techniques available with in vitro or ex vivo assessments to evaluate LFN-mediated imbalance by direct administration of preventive chemicals into the vestibule. Our findings demonstrated the usefulness of an explant culture of the utricle with a fluorescent styryl dye, FM1-43FX. In addition, examination of the morphology of the otoconial membrane with explant cultures of utricles was conducted to determine the risk of LFN. Ex vivo exposure of the utricle to LFN at 100 Hz, 95 dB for 1 hr induced breaks in the otoconial membrane as well as decreased uptake of FM1-43FX in hair cells. Taken together, the results of this study provide a novel technique for assessing the risk of LFN exposure using an ex vivo experiment.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021/04/05
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/15287394.2020.1746945
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1528-7394
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1087-2620
書誌情報 en : Journal of Toxicology and Environmental Health, Part A

巻 83, 号 5, p. 215-218, 発行日 2020-04-05
著者版フラグ
値 author
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