{"created":"2021-03-01T06:38:38.618592+00:00","id":30335,"links":{},"metadata":{"_buckets":{"deposit":"d1acc277-e5fe-4015-8f6a-12ede6558fea"},"_deposit":{"id":"30335","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30335"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030335","sets":["499:500:501"]},"author_link":["100640","100641","100642","100643","100644","100645"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"218","bibliographicPageStart":"215","bibliographicVolumeNumber":"83","bibliographic_titles":[{"bibliographic_title":"Journal of Toxicology and Environmental Health, Part A","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Health risks attributed to low-frequency noise (LFN) exposure are a serious global issue. Therefore, the development of a method for a prevention based upon risk assessments for LFN is important. Previously in vivo exposure of mice to LFN at 100 Hz, 95 dB for 1 hr produced imbalance with breakage of the otoconial membrane, which covers hair cells as well as impaired activity of hair cells in the vestibule. However, methods for inhibition of LFN-mediated imbalance have not been developed. At present, there are no apparent techniques available with in vitro or ex vivo assessments to evaluate LFN-mediated imbalance by direct administration of preventive chemicals into the vestibule. Our findings demonstrated the usefulness of an explant culture of the utricle with a fluorescent styryl dye, FM1-43FX. In addition, examination of the morphology of the otoconial membrane with explant cultures of utricles was conducted to determine the risk of LFN. Ex vivo exposure of the utricle to LFN at 100 Hz, 95 dB for 1 hr induced breaks in the otoconial membrane as well as decreased uptake of FM1-43FX in hair cells. Taken together, the results of this study provide a novel technique for assessing the risk of LFN exposure using an ex vivo experiment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2021/04/05","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/15287394.2020.1746945","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Toxicology and Environmental Health, Part A on 05/04/2020, available online: http://www.tandfonline.com/10.1080/15287394.2020.1746945.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1528-7394","subitem_source_identifier_type":"PISSN"}]},"item_10_source_id_62":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"1087-2620","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohgami, Nobutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"He, Tingchao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshino-Negishi, Reina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gu, Yishuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Xiang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100645","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-05"}],"displaytype":"detail","filename":"UTEH-2020-0106_R1_repository.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"UTEH-2020-0106_R1_repository","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30335/files/UTEH-2020-0106_R1_repository.pdf"},"version_id":"8a18dc20-4c14-4c15-b289-6f1755f0491e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"low frequency noise","subitem_subject_scheme":"Other"},{"subitem_subject":"risk assessment","subitem_subject_scheme":"Other"},{"subitem_subject":"vestibule","subitem_subject_scheme":"Other"},{"subitem_subject":"otoconial membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"balance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"30335","relation_version_is_last":true,"title":["A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:23:43.193286+00:00"}