{"created":"2021-03-01T06:38:43.515762+00:00","id":30409,"links":{},"metadata":{"_buckets":{"deposit":"fa4912d7-ea65-4662-b6bf-a38e8743a93a"},"_deposit":{"created_by":17,"id":"30409","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"30409"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030409","sets":["499:508:509:2518"]},"author_link":["100992","100993","100994"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"397","bibliographicPageStart":"391","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pathological spectrum of nonalcoholic fatty liver disease includes simple steatosis and nonalcoholic steatohepatitis (NASH), the latter of which is the leading cause of cirrhosis and hepatocellular carcinoma. The available evidence shows that parenchymal cell injury and death trigger inflammation and tissue fibrosis. During the development of liver fibrosis, stromal cells dramatically changes in their cellular component and activation status responding to hepatocyte injury due to various etiologies. It is important to understand how cell death induces chronic inflammation and fibrosis, and the disease-specific macrophages and fibroblasts responsible for NASH development under metabolic stress. This review discusses recent progress in the understanding the pathogenesis of NASH, focusing on disease-specific macrophages and fibroblasts.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16H05171, 16KT0110, 16K08732, 17H05500, and 19K07475) and AMED-CREST (JP19gm1210009).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.82.3.391","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html ","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itoh, Michiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suganami, Takayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"100994","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-04"}],"displaytype":"detail","filename":"01_Itoh.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"01_Itoh.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30409/files/01_Itoh.pdf"},"version_id":"4d00cb33-ddb8-4f46-967e-24a7e039148e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chronic inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophages","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblasts","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["2518"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-04"},"publish_date":"2020-09-04","publish_status":"0","recid":"30409","relation_version_is_last":true,"title":["Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T02:43:43.953478+00:00"}