{"created":"2021-03-01T06:38:43.784370+00:00","id":30413,"links":{},"metadata":{"_buckets":{"deposit":"510ce78d-ea75-4d41-8c94-863cf2f25142"},"_deposit":{"created_by":17,"id":"30413","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"30413"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030413","sets":["499:508:509:2518"]},"author_link":["101020","101021","101022","101023","101024","101025","101026"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"435","bibliographicPageStart":"425","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the effect of adipose-derived regenerative cells (ADRC) on bladder functions in a rat model of detrusor underactivity (DU) induced by bladder over-distention.\nAdult female Sprague Dawley rats were divided into 3 groups: sham group (control); over-distention group; and over-distention with ADRC treatment group. Bladder was over-distended with saline (2.7mL) on day 1, 8, 15 and 22 of the study. ADRCs, which were harvested from male F344 rats, expanded via culture, were injected into the bladder wall at day 15. Cystometry and in vitro organ bath functional studies were performed on day 28. Moreover, histological assessment of the bladder was performed.\nIn cystometry, significant prolongation of the inter-contraction interval (ICI) and decrease of voiding ef-ficiency (VE) were observed in the over-distention group, compared to that in the control group. Significant improvement in ICI and VE was seen in the ADRC treatment group in comparison with the over-distention group. The over-distention group showed significantly weaker bladder contractile responses to carbachol and electrical field stimulation than the control group, while bladder contractile responses were significantly stronger in the ADRC treatment group than that in the over-distention group. The over-distention group showed substantial fibrosis of the bladder compared to the control group, whereas bladder fibrosis was alleviated in the ADRC treatment group.\nIn conclusion, the injection of ADRC into bladder wall improved bladder dysfunction and histological changes induced by bladder over-distention. ADRCs-based regenerative therapy could be novel treatment for DU.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.82.3.425","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html ","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsukawa, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Funahashi, Yasuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Majima, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takai, Shun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Tokunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gotoh, Momokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101026","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-04"}],"displaytype":"detail","filename":"05_Mori.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"05_Mori.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30413/files/05_Mori.pdf"},"version_id":"7b66209c-82b1-4f33-bdfb-879e363288cd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"underactive bladder","subitem_subject_scheme":"Other"},{"subitem_subject":"adipose-derived regenerative cells","subitem_subject_scheme":"Other"},{"subitem_subject":"over-distention","subitem_subject_scheme":"Other"},{"subitem_subject":"bladder function","subitem_subject_scheme":"Other"},{"subitem_subject":"detrusor underactivity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Therapeutic effect of adipose-derived regenerative cells on bladder function in rats with underactive bladder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Therapeutic effect of adipose-derived regenerative cells on bladder function in rats with underactive bladder","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["2518"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-04"},"publish_date":"2020-09-04","publish_status":"0","recid":"30413","relation_version_is_last":true,"title":["Therapeutic effect of adipose-derived regenerative cells on bladder function in rats with underactive bladder"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T02:43:54.036769+00:00"}