{"created":"2021-03-01T06:38:44.313221+00:00","id":30421,"links":{},"metadata":{"_buckets":{"deposit":"21b51a5c-d9b9-4af3-a3ea-59f9aa9646a1"},"_deposit":{"created_by":17,"id":"30421","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"30421"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030421","sets":["499:508:509:2518"]},"author_link":["101072","101073","101074","101075","101076","101077","101078","101079"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"518","bibliographicPageStart":"509","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sasa veitchii and other Sasa species are traditional medicinal herbs belonging to a group of Japanese bamboos collectively called Kumazasa, and these species possess the potential for a wide variety of uses. The present study aimed to elucidate the anticancer mechanisms exerted by S. veitchii extract (SE) against a human breast cancer cell line, MCF-7 cells. Freeze-dried Sunchlon® was used as the SE, and cell proliferation activity was measured using the [3H]-thymidine incorporation assay. Induction of apoptosis was assessed via Annexin V and caspase-3 fluorescent staining, the induction of necrosis was measured via propidium iodide staining, and cell cycle-related protein expression was determined using western blot-ting. The IC50 value of the SE was 7.7 μg/mL in MCF-7 cells. Although the primary active ingredient in Sunchlon® is sodium copper chlorophyllin (0.25%), the present results indicated that ingredients other than SCC exert anti-cancer activities (the IC50 value of SCC was 715 μg/mL), and late apoptosis or necrosis was induced in an SE dose-dependent manner. The expression levels of cyclin D1 and Cdk6 were decreased after SE treatment, and there was no change in the Cdk1/2 expression levels. Additionally, the expression of the necrosis-related cell death indicators RIP1 and RIP3 was increased in response to high-dose SE treatments, and this was indicative of cells preparing for programmed cell death. SE induces cell death in MCF-7 cells via the inhibition of cyclin D1 expression at low concentrations, and this extract induces programmed necrosis (necroptosis) by potentiating RIP1/RIP3 expression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.82.3.509","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html ","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichimaru, Yoshimi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanaeda, Natsuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tominaga, Sarah","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzui, Masumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Hirohisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakao, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101079","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-04"}],"displaytype":"detail","filename":"13_Ichimaru.pdf","filesize":[{"value":"8.0 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"13_Ichimaru.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30421/files/13_Ichimaru.pdf"},"version_id":"2a132004-d320-4da2-a1b1-571070381608"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sasa veitchii","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclin D1","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"sodium copper chlorophyllin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["2518"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-04"},"publish_date":"2020-09-04","publish_status":"0","recid":"30421","relation_version_is_last":true,"title":["Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T02:44:13.517290+00:00"}