{"created":"2021-03-01T06:38:52.078539+00:00","id":30538,"links":{},"metadata":{"_buckets":{"deposit":"60c4bd96-0170-493d-9e00-191a67a352d7"},"_deposit":{"id":"30538","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30538"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030538","sets":["1903:1904:1905"]},"author_link":["101639","101640","101641","101642"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageStart":"115558","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-π-A sensitizers consist of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-π-A photosensitizers for PDT.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2022-07-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmc.2020.115558","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0968-0896","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fuse, Shinichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriya, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101642","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-01"}],"displaytype":"detail","filename":"revised_manuscript.pdf","filesize":[{"value":"648.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"revised_manuscript","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30538/files/revised_manuscript.pdf"},"version_id":"dd728c45-ceae-43d5-90a7-878c415dc1ed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Photodynamic therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Organic dye","subitem_subject_scheme":"Other"},{"subitem_subject":"Sensitizer","subitem_subject_scheme":"Other"},{"subitem_subject":"Singlet oxygen","subitem_subject_scheme":"Other"},{"subitem_subject":"Endocytosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["1905"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-13"},"publish_date":"2020-10-13","publish_status":"0","recid":"30538","relation_version_is_last":true,"title":["Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:24:04.093729+00:00"}