{"created":"2021-03-01T06:38:58.118294+00:00","id":30628,"links":{},"metadata":{"_buckets":{"deposit":"58733bae-4496-412c-8a78-e90cda9f5cf9"},"_deposit":{"id":"30628","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30628"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00030628","sets":["320:2524:2525:2533"]},"author_link":["101799"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"131","bibliographicPageStart":"91","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Memoirs of the School of Engineering, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Some chemical modifications of natural nucleosides based on the general organic chemistry have been carried out. Base catalyzed elimination reactions at the 2', 3'-positions of purine and pyrimidine nucleosides proved to be regiospecific. In the pyrimidine series, the resulting 2', 3'-olefins with a leaving group at the C-2' readily formed the corresponding 3'-deoxy-2'-keto-nucleosides, an entirely new class of bioorganic substances.<br/>Exploratory experiments aiming at base-sugar cyclization at the 4' -positions of nucleosides led to the N[3],C[4']-cyclization with concomitant decyclization of the base moiety in adenosine series, while in the pyrimidine series the first synthesis of O[2],C[4']-Crcyclonucleosides was achieved. Synthetic studies on the hitherto unexploited nitrogen-bridged cyclonucleosides were extensively conducted. The major topics cover (a) general synthesis of 2,3'-imino and (substituted-imino) pyrimidine nucleosides,(b) regio and stereospecific synthesis of some reversed nucleosides through protected pyrimidine 6,5'-N-cyclonucleosides, (c) general synthesis of purine 8,5'-N-cyclonucleosides, (d) synthesis and chemistry of purine 8,2'- and 8,3'-long-bridged cyclonucleosides, (e) hydrolytic cleavage of the nitrogen bridge in the 2,2'- and 2,3'-(substituted-imino) pyrimidine nucleosides,(f) molecular rearrangements through the fission of the glycosidic bond in the general N-bridged cyclonucleosides, (g) strain-assisted hydrolysis of the nitrogen bridge of a pyrimidine multi-cyclic N-cyclonucleoside and (h) synthesis and chemistry of piperidine sugar uracil nucleosides. The final topic presents the synthesis and chemistry of 3-deoxy-3-nitro-hexopyranosyl nucleosides in both pyrimidine and purine series. The major results are stereoselective Michael addition reactions of various nucleophiles to the 3-nitro-2,3-unsaturated sugar nucleosides in both cases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/memsenu.48.2.91","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"School of Engineering, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0919-0805","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minamoto, Katsumaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"101799","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"48-2-01.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"48-2-01.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/30628/files/48-2-01.pdf"},"version_id":"1ee99600-8746-4f05-a842-a0392f4b2b96"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chemical modifications of natural nucleosides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chemical modifications of natural nucleosides","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["2533"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"30628","relation_version_is_last":true,"title":["Chemical modifications of natural nucleosides"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:45:37.765150+00:00"}