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Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis
http://hdl.handle.net/2237/00033216
http://hdl.handle.net/2237/00033216c2d9d6d6-aaa0-4357-b28d-0614ab9fd819
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-18 | |||||
タイトル | ||||||
タイトル | Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis | |||||
言語 | en | |||||
著者 |
Tatsukawa, Hideki
× Tatsukawa, Hideki× Takeuchi, Taishu× Shinoda, Yoshiki× Hitomi, Kiyotaka |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transglutaminase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kidney fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Substrate identification | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Crosslinking | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The transglutaminase (TGase) family consists of eight isozymes that catalyze Ca^2+-dependent crosslink formation between glutamine and lysine residues of proteins. In the pathogenesis of various chronic diseases, among the TGase isozymes, TG2 in particular is upregulated and contributes to a critical role in fibrosis development and progression via the stabilization of extracellular matrix proteins and activation of TGF-β. Although TG2 has been considered a key enzyme in fibrosis, the causative role of TG2 and involvement of other isozymes remain unclear. We have recently developed a comprehensive analysis method targeting the isozyme-specific substrates of TGase in liver and kidney fibrosis. In this review article, we introduce a previously developed method for determining the activity and tissue distribution of TGase and for the detecting and identification of TGase substrates in an isozyme-specific manner. Using our comprehensive analysis method, we newly characterized the overlapping profile data regarding potential substrates of TG1 and TG2 that have been identified in liver and kidney fibrosis to date. Our results obtained by comparing the specificity and similarity of potential TGase substrates between different tissue fibrosis models provide a deeper understanding regarding the specific and common pathways in disease pathogenesis and progression. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2022-09-01 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.ab.2020.113629 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0003-2697 | |||||
書誌情報 |
en : Analytical Biochemistry 巻 604, p. 113629, 発行日 2020-09-01 |
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著者版フラグ | ||||||
値 | author |