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  1. D400 創薬科学研究科
  2. D400a 雑誌掲載論文
  3. 学術雑誌

Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis

http://hdl.handle.net/2237/00033216
http://hdl.handle.net/2237/00033216
c2d9d6d6-aaa0-4357-b28d-0614ab9fd819
名前 / ファイル ライセンス アクション
YABIO_2019_982_Original_V0.pdf YABIO_2019_982_Original_V0 (3.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-12-18
タイトル
タイトル Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis
言語 en
著者 Tatsukawa, Hideki

× Tatsukawa, Hideki

WEKO 102630

en Tatsukawa, Hideki

Search repository
Takeuchi, Taishu

× Takeuchi, Taishu

WEKO 102631

en Takeuchi, Taishu

Search repository
Shinoda, Yoshiki

× Shinoda, Yoshiki

WEKO 102632

en Shinoda, Yoshiki

Search repository
Hitomi, Kiyotaka

× Hitomi, Kiyotaka

WEKO 102633

en Hitomi, Kiyotaka

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Transglutaminase
キーワード
主題Scheme Other
主題 Liver fibrosis
キーワード
主題Scheme Other
主題 Kidney fibrosis
キーワード
主題Scheme Other
主題 Substrate identification
キーワード
主題Scheme Other
主題 Crosslinking
抄録
内容記述 The transglutaminase (TGase) family consists of eight isozymes that catalyze Ca^2+-dependent crosslink formation between glutamine and lysine residues of proteins. In the pathogenesis of various chronic diseases, among the TGase isozymes, TG2 in particular is upregulated and contributes to a critical role in fibrosis development and progression via the stabilization of extracellular matrix proteins and activation of TGF-β. Although TG2 has been considered a key enzyme in fibrosis, the causative role of TG2 and involvement of other isozymes remain unclear. We have recently developed a comprehensive analysis method targeting the isozyme-specific substrates of TGase in liver and kidney fibrosis. In this review article, we introduce a previously developed method for determining the activity and tissue distribution of TGase and for the detecting and identification of TGase substrates in an isozyme-specific manner. Using our comprehensive analysis method, we newly characterized the overlapping profile data regarding potential substrates of TG1 and TG2 that have been identified in liver and kidney fibrosis to date. Our results obtained by comparing the specificity and similarity of potential TGase substrates between different tissue fibrosis models provide a deeper understanding regarding the specific and common pathways in disease pathogenesis and progression.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2022-09-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ab.2020.113629
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0003-2697
書誌情報 en : Analytical Biochemistry

巻 604, p. 113629, 発行日 2020-09-01
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