{"created":"2021-03-01T06:39:26.241320+00:00","id":31053,"links":{},"metadata":{"_buckets":{"deposit":"3b0870e0-2736-48ab-a88c-40a2ffb2e952"},"_deposit":{"id":"31053","owners":[],"pid":{"revision_id":0,"type":"depid","value":"31053"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00031053","sets":["499:500:501"]},"author_link":["102700","102701","102702","102703","102704","102705","102706","102707","102708","102709","102710","102711","102712","102713"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"35","bibliographicPageEnd":"5794","bibliographicPageStart":"5782","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Oncogene","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non–PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that allow non–PB-ATLs to proliferate and invade compared with PB-ATLs. Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non–PB-ATLs compared with PB-ATLs. The HGF membrane receptor, c-Met, was expressed in PB-ATL and non–PB-ATL cell lines, but CCR2, a CCL2 receptor, was not. Immunohistochemical analysis in clinical ATLs revealed high HGF expression in LNs, pharynx, bone marrow, and tonsils. The HGF/c-Met signaling pathway was active downstream in non–PB-ATLs. Downregulation of HGF/c-Met by siRNA or chemical inhibitors decreased in vitro and in vivo proliferation and invasion by non–PB-ATLs. Treatment with bromodomain and extra-terminal motif inhibitor suppressed HGF expression and decreased levels of histone H3 lysine 27 acetylation (H3K27Ac) and bromodomain-containing protein 4 (BRD4) binding promoter and enhancer regions, suppressing non–PB-ATL cellular growth. Our data indicate H3K27Ac/BRD4 epigenetics regulates the HGF/c-MET pathway in ATLs; targeting this pathway may improve treatment of aggressive non–PB-ATLs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2021/02/27","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41388-020-01393-x","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0950-9232","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Asahi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ri, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusumoto, Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komatsu, Hirokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishida, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inagaki, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iida, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"102713","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-27"}],"displaytype":"detail","filename":"NAGOYARepository_Kondo_Yutaka.pdf","filesize":[{"value":"1.8 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leukemia/lymphoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-23"},"publish_date":"2020-12-23","publish_status":"0","recid":"31053","relation_version_is_last":true,"title":["Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:43:31.228512+00:00"}