@article{oai:nagoya.repo.nii.ac.jp:00031433,
 author = {Xu, Huadong and Hashimoto, Kazunori and Maeda, Masao and Azimi, Mohammad Daud and Fayaz, Said Hafizullah and Chen, Wei and Hamajima, Nobuyuki and Kato, Masashi},
 journal = {Environmental Pollution},
 month = {Nov},
 note = {WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells., ファイル公開：2022-11-01},
 title = {High levels of boron promote anchorage-independent growth of nontumorigenic cells},
 volume = {266},
 year = {2020}
}