{"created":"2021-03-01T06:39:51.629375+00:00","id":31433,"links":{},"metadata":{"_buckets":{"deposit":"addb6fc4-f0be-43aa-abf9-39fae509ce1e"},"_deposit":{"id":"31433","owners":[],"pid":{"revision_id":0,"type":"depid","value":"31433"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00031433","sets":[]},"author_link":["103673","103674","103675","103676","103677","103678","103679","103680"],"item_10_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"115094","bibliographicVolumeNumber":"266","bibliographic_titles":[{"bibliographic_title":"Environmental Pollution","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 \u03bcM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 \u03bcM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2022-11-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.envpol.2020.115094","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"\u6a29\u5229","attribute_value_mlt":[{"subitem_rights":"\u00a9 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN\uff08print\uff09","attribute_value_mlt":[{"subitem_source_identifier":"0269-7491","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"\u51fa\u7248\u30bf\u30a4\u30d7","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"\u30a2\u30af\u30bb\u30b9\u6a29","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xu, Huadong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Azimi, Mohammad Daud","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fayaz, Said Hafizullah","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chen, Wei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamajima, Nobuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"103680","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-01"}],"displaytype":"detail","filename":"ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf","filesize":[{"value":"763.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ENVIRONMENTAL_POLLUTION_2020_266_115094","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/31433/files/ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf"},"version_id":"54e48fa8-87d3-4d41-bcda-89cbd40bd1e7"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Boron","subitem_subject_scheme":"Other"},{"subitem_subject":"Well drinking water","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumorigenic risk","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumorigenic pathway","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High levels of boron promote anchorage-independent growth of nontumorigenic cells","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"High levels of boron promote anchorage-independent growth of nontumorigenic cells","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["499/500/501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-15"},"publish_date":"2021-02-15","publish_status":"0","recid":"31433","relation_version_is_last":true,"title":["High levels of boron promote anchorage-independent growth of nontumorigenic cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-08-09T02:49:21.620173+00:00"}