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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Lithium promotes malignant transformation of nontumorigenic cells in vitro

http://hdl.handle.net/2237/00033614
e353ed93-aa76-40e3-b6e5-85df26ab633e
名前 / ファイル ライセンス アクション
SCIENCE_OF_THE_TOTAL_ENVIRONMENT_2020_744_140830.pdf SCIENCE_OF_THE_TOTAL_ENVIRONMENT_2020_744_140830 (8.7 MB)
 Download is available from 2022/11/19.
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-15
タイトル
タイトル Lithium promotes malignant transformation of nontumorigenic cells in vitro
著者 Sudo, Makoto

× Sudo, Makoto

WEKO 103681

Sudo, Makoto

Search repository
Hashimoto, Kazunori

× Hashimoto, Kazunori

WEKO 103682

Hashimoto, Kazunori

Search repository
Yoshinaga, Masafumi

× Yoshinaga, Masafumi

WEKO 103683

Yoshinaga, Masafumi

Search repository
Azimi, Mohammad Daud

× Azimi, Mohammad Daud

WEKO 103684

Azimi, Mohammad Daud

Search repository
Fayaz, Said Hafizullah

× Fayaz, Said Hafizullah

WEKO 103685

Fayaz, Said Hafizullah

Search repository
Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 103686

Hamajima, Nobuyuki

Search repository
Kondo-Ida, Lisa

× Kondo-Ida, Lisa

WEKO 103687

Kondo-Ida, Lisa

Search repository
Yanagisawa, Kiyoshi

× Yanagisawa, Kiyoshi

WEKO 103688

Yanagisawa, Kiyoshi

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 103689

Kato, Masashi

Search repository
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Afghanistan
キーワード
主題Scheme Other
主題 Drinking water
キーワード
主題Scheme Other
主題 Lithium
キーワード
主題Scheme Other
主題 Oncogenesis
キーワード
主題Scheme Other
主題 Progression
キーワード
主題Scheme Other
主題 Transformation
抄録
内容記述 Because of the deficiency of water caused by the regional disparities of rainfall due to global warming, attention has been given to the use of well water as drinking water in developing countries. Our fieldwork study in Afghanistan showed that there was a maximum value of 3371 μg/L and an average value of 233 μg/L of lithium in well drinking water. Since the level of lithium in well water is higher than the levels in other countries, we investigated the health risk of lithium. After confirming no influence of ≤1000 μM lithium on cell viability, we found that lithium at concentrations of 100 and 500 μM promoted anchorage-independent growth of human immortalized keratinocytes (HaCaT) and lung epithelial cells (BEAS-2B) but not that of human keratinocytic carcinoma cells (HSC-5) or lung epithelial carcinoma cells (A549). The same concentrations of lithium also promoted phosphorylation of c-SRC and MEK/ERK but not that of AKT in the keratinocytes. Inhibitors of c-SRC (PP2) and MEK (PD98059) suppressed the lithium-induced increase in anchorage-independent growth of the keratinocytes. Our results suggested that lithium promoted transformation of nontumorigenic cells rather than progression of tumorigenic cells with preferential activation of the c-SRC/MEK/ERK pathway. Since previous pharmacokinetics studies indicated that it is possible for the serum level of lithium to reach 100 μM by drinking 2.5 L of water containing 3371 μg/L of lithium per day, the high level of lithium contamination in well drinking water in Kabul might be a potential oncogenic risk in humans.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2022-11-20
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.scitotenv.2020.140830
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0048-9697
書誌情報 Science of The Total Environment

巻 744, p. 140830, 発行日 2020-11-20
著者版フラグ
値 author
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