{"_buckets": {"deposit": "72fa1cae-529f-43f6-8642-f54186410825"}, "_deposit": {"id": "31434", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "31434"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00031434"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-11-20", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "140830", "bibliographicVolumeNumber": "744", "bibliographic_titles": [{"bibliographic_title": "Science of The Total Environment"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Because of the deficiency of water caused by the regional disparities of rainfall due to global warming, attention has been given to the use of well water as drinking water in developing countries. Our fieldwork study in Afghanistan showed that there was a maximum value of 3371 \u03bcg/L and an average value of 233 \u03bcg/L of lithium in well drinking water. Since the level of lithium in well water is higher than the levels in other countries, we investigated the health risk of lithium. After confirming no influence of \u22641000 \u03bcM lithium on cell viability, we found that lithium at concentrations of 100 and 500 \u03bcM promoted anchorage-independent growth of human immortalized keratinocytes (HaCaT) and lung epithelial cells (BEAS-2B) but not that of human keratinocytic carcinoma cells (HSC-5) or lung epithelial carcinoma cells (A549). The same concentrations of lithium also promoted phosphorylation of c-SRC and MEK/ERK but not that of AKT in the keratinocytes. Inhibitors of c-SRC (PP2) and MEK (PD98059) suppressed the lithium-induced increase in anchorage-independent growth of the keratinocytes. Our results suggested that lithium promoted transformation of nontumorigenic cells rather than progression of tumorigenic cells with preferential activation of the c-SRC/MEK/ERK pathway. Since previous pharmacokinetics studies indicated that it is possible for the serum level of lithium to reach 100 \u03bcM by drinking 2.5 L of water containing 3371 \u03bcg/L of lithium per day, the high level of lithium contamination in well drinking water in Kabul might be a potential oncogenic risk in humans.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2022-11-20", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.scitotenv.2020.140830", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0048-9697", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sudo, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "103681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "103682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshinaga, Masafumi"}], "nameIdentifiers": [{"nameIdentifier": "103683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Azimi, Mohammad Daud"}], "nameIdentifiers": [{"nameIdentifier": "103684", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fayaz, Said Hafizullah"}], "nameIdentifiers": [{"nameIdentifier": "103685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamajima, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "103686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo-Ida, Lisa"}], "nameIdentifiers": [{"nameIdentifier": "103687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagisawa, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "103688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "103689", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-20"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2022/11/19.", "file_order": 0, "filename": "SCIENCE_OF_THE_TOTAL_ENVIRONMENT_2020_744_140830.pdf", "filesize": [{"value": "8.7 MB"}], "format": "application/pdf", "future_date_message": "Download is available from 2022/11/19.", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 8700000.0, "url": {"label": "SCIENCE_OF_THE_TOTAL_ENVIRONMENT_2020_744_140830", "url": "https://nagoya.repo.nii.ac.jp/record/31434/files/SCIENCE_OF_THE_TOTAL_ENVIRONMENT_2020_744_140830.pdf"}, "version_id": "200096ab-5406-40f5-ae36-9b5422202004"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Afghanistan", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Drinking water", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lithium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oncogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Progression", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transformation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Lithium promotes malignant transformation of nontumorigenic cells in vitro", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Lithium promotes malignant transformation of nontumorigenic cells in vitro"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00033614", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2021-02-15"}, "publish_date": "2021-02-15", "publish_status": "0", "recid": "31434", "relation": {}, "relation_version_is_last": true, "title": ["Lithium promotes malignant transformation of nontumorigenic cells in vitro"], "weko_shared_id": null}