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An Amino Acid-Swapped Genetic Code
http://hdl.handle.net/2237/00033615
http://hdl.handle.net/2237/00033615ffd025e4-ab06-42bf-9fdd-b921ebf154e5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AS_genetic_code_article_210208 (5.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-15 | |||||
| タイトル | ||||||
| タイトル | An Amino Acid-Swapped Genetic Code | |||||
| 言語 | en | |||||
| 著者 |
Fujino, Tomoshige
× Fujino, Tomoshige× Tozaki, Masahiro× Murakami, Hiroshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Synthetic Biology], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-NB9DN3ZGG4GRS9ETGPWT].” | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genetic code | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell-free translation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tRNA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aminoacyl-tRNA synthetase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genetic firewall | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Preventing the escape of hazardous genes from genetically modified organisms (GMOs) into the environment is one of the most important issues in biotechnology research. Various strategies were developed to create “genetic firewalls” that prevent the leakage of GMOs; however, they were not specially designed to prevent the escape of genes. To address this issue, we developed amino acid (AA)-swapped genetic codes orthogonal to the standard genetic code, namely SL (Ser and Leu were swapped) and SLA genetic codes (Ser, Leu, and Ala were swapped). From mRNAs encoded by the AA-swapped genetic codes, functional proteins were only synthesized in translation systems featuring the corresponding genetic codes. These results clearly demonstrated the orthogonality of the AA-swapped genetic codes against the standard genetic code and their potential to function as “genetic firewalls for genes”. Furthermore, we propose “a codon-bypass strategy” to develop a GMO with an AA-swapped genetic code. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2021-10-16 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1021/acssynbio.0c00196 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 2161-5063 | |||||
| 書誌情報 |
en : ACS Synthetic Biology 巻 9, 号 10, p. 2703-2713, 発行日 2020-10-16 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
