{"created":"2021-03-01T06:10:24.007811+00:00","id":3921,"links":{},"metadata":{"_buckets":{"deposit":"14701d04-03e2-46b3-b5f5-1c56a393bd13"},"_deposit":{"created_by":17,"id":"3921","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"3921"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00003921","sets":["499:508:509:511"]},"author_link":["9984","9985","9986","9987","9988","9989","9990","9991"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"39","bibliographicPageStart":"25","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Eleven Japanese hemophilia A patients with anti-factor VIII (FVIII)a) inhibitors were studied to localize both their inhibitory antibody epitopes and their genotypes. The inhibitor epitopes were studied in nine severe hemophilia A patients by means of a scanning method using the oligopeptide panel covering the FVIII polypeptides without the B domain. The 107 15 mer-peptides were synthesized on solid-phase pins and analyzed for their reactivity with diluted patient plasma. As indicated previously, a series of peptides corresponding to the A2 and C2 domains were recognized by plasma antibodies from 2 patients and 4 patients, respectively. In contrast, all the antibodies bound to several epitopes in the A3 domain, while an epitope 1809-1821 covering the putative factor IX binding site was found in 3 patients. Southern blotting analysis showed that 8 out of 11 patients had either gene deletions or inversions of the FVIII gene, indicating a higher proportion of gross gene alterations in inhibitor-positive hemophilia A patients. However, the correlation of gene abnormality type with epitope location was not fully established.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/5351"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.63.1-2.25","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugihara, Takuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Isao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Tetsuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsushita, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Hidehiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9991","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"nj6314.pdf","filesize":[{"value":"267.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nj6314.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/3921/files/nj6314.pdf"},"version_id":"ad27a76e-ab1b-49a8-a791-131f8db133a8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Factor VIII","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemophilia A","subitem_subject_scheme":"Other"},{"subitem_subject":"Factor VIII inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"Southern blotting","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene inversion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["511"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-02-03"},"publish_date":"2006-02-03","publish_status":"0","recid":"3921","relation_version_is_last":true,"title":["Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:58:58.591148+00:00"}