{"created":"2021-03-01T06:10:24.389251+00:00","id":3927,"links":{},"metadata":{"_buckets":{"deposit":"ab10ec3a-a997-4cdf-8a51-3dc4eb1141fc"},"_deposit":{"created_by":17,"id":"3927","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"3927"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00003927","sets":["499:508:509:512"]},"author_link":["10016"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"98","bibliographicPageStart":"91","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To study the regulation of [Na+]i and [Ca2+]i during myocardial ischemia/reperfusion, [Na+]i and [Ca2+]i were measured simultaneously using guinea pig ventricular myocytes which were dual-loaded with SBFI/AM and fluo-3/AM. It was suggested that: (1) [Na+]i increased during metabolic inhibition (MI: 3.3 mM amytal and 5 μM CCCP) by both the activated Na+ influx via Na+/H+ exchange and the suppressed Na+ extrusion via the Na+/K+ pump; (2) Na+/Ca2+ exchange was inhibited during MI, causing the dissociation between [Na+]i and [Ca2+]I; (3) Na+/Ca2+ exchange could be reactivated by energy repletion, resulting in a significant increase in [Ca2+]i, Furthermore, a Ca2+ influx via the reverse-mode of Na+/Ca2+ exchange may play a key role in the mechanism of Ca2+ overload on reoxygenation; and (4) cell contracture during MI was related to rigor due to energy depletion, while cell contracture after energy repletion was likely to be related to Ca2+ overload.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/5357"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.63.3-4.91","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Hideharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10016","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"nj6332.pdf","filesize":[{"value":"92.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nj6332.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/3927/files/nj6332.pdf"},"version_id":"86935ac5-f4e6-47ab-811e-e6f278e7e548"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"myocardial ischemia","subitem_subject_scheme":"Other"},{"subitem_subject":"reperfusion","subitem_subject_scheme":"Other"},{"subitem_subject":"[Na+]","subitem_subject_scheme":"Other"},{"subitem_subject":"[Ca2+]","subitem_subject_scheme":"Other"},{"subitem_subject":"Na+/H+ exchange","subitem_subject_scheme":"Other"},{"subitem_subject":"Na+/K+ pump","subitem_subject_scheme":"Other"},{"subitem_subject":"Na+/Ca2+","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathogenesis and the role of Ca2+ overload during myocardial ischemia/reperfusion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathogenesis and the role of Ca2+ overload during myocardial ischemia/reperfusion","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["512"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-02-03"},"publish_date":"2006-02-03","publish_status":"0","recid":"3927","relation_version_is_last":true,"title":["Pathogenesis and the role of Ca2+ overload during myocardial ischemia/reperfusion"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:59:13.761499+00:00"}