{"created":"2021-03-01T06:10:25.338245+00:00","id":3942,"links":{},"metadata":{"_buckets":{"deposit":"72cc8fc7-8392-463e-b0fa-d30fdbeb9eff"},"_deposit":{"id":"3942","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3942"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00003942"},"item_9_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science"}]}]},"item_9_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Abnormal contraction of vascular smooth muscle contributes to a variety of diseases such as hypertension and vasospasm in coronary and cerebral arteries. An increment in a cytoplasmic Ca2+ concentration is the key event in smooth muscle contraction. However, smooth muscle contraction is modified upon the stimulation by agonists as well as in some pathophysiological situations in Ca2+-independent mechanism. The molecular mechanism underlying this modulation was not elucidated. Recent studies have shown the important role of small GTPase Rho and its effector, Rho-associated kinase (Rho-kinase)/ROK/ROCK in Ca2+-independent regulation of smooth muscle contraction. The Rho/Rho-kinase pathway modulates the phosphorylation level of myosin light chain (MLC) of myosin II, mainly through the inhibition of myosin phosphatase, and contributes to the agonist-induced Ca2+-sensitization in smooth muscle contraction. The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases.","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/5374"}]},"item_9_identifier_registration":{"attribute_name":"ID\u767b\u9332","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.65.1-2.1","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine"}]},"item_9_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_text_14":{"attribute_name":"\u30d5\u30a9\u30fc\u30de\u30c3\u30c8","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawano, Yoji"}],"nameIdentifiers":[{"nameIdentifier":"10069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"10070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaibuchi, Kozo"}],"nameIdentifiers":[{"nameIdentifier":"10071","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"nj6511.pdf","filesize":[{"value":"80.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nj6511.pdf","url":"https://nagoya.repo.nii.ac.jp/record/3942/files/nj6511.pdf"},"version_id":"5fdc7d60-e8cd-4211-9932-e294bedb7c62"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Rho","subitem_subject_scheme":"Other"},{"subitem_subject":"Rho-kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"myosin light chain (MLC)","subitem_subject_scheme":"Other"},{"subitem_subject":"myosin phosphatase","subitem_subject_scheme":"Other"},{"subitem_subject":"myosin-binding subunit (MBS)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+-sensitization","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Smooth muscle contraction by small GTPase Rho","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Smooth muscle contraction by small GTPase Rho"}]},"item_type_id":"9","owner":"1","path":["499/508/509/515"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2006-02-08"},"publish_date":"2006-02-08","publish_status":"0","recid":"3942","relation_version_is_last":true,"title":["Smooth muscle contraction by small GTPase Rho"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T20:49:02.550149+00:00"}