@article{oai:nagoya.repo.nii.ac.jp:00003977,
 author = {Naito, Yuko and Suzuki, Noriko and Huang, Pengyu and Hasegawa, Hitoki and Sohara, Yasuyoshi and Iwamoto, Takashi and Hamaguchi, Michinari},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Jun},
 note = {Malignant transformation of cells is frequently associated with an augmented production of hyaluronan and the subsequent formation of a hyaluronan-matrix. In v-Src-transformed cells, hyaluronan directly activate cell motility in a tumor-specifi c manner. Despite its importance, the mechanism by which v-Src activates hyaluronan production remains unclear. Here we report that multiple signaling pathways are required for the augmented production of hyaluronan. Either the expression of a dominant negative Ras or the treatment of cells with manumycin A, a Ras farnesyltransferase inhibitor, was able to suppress hyaluronan production. In contrast, expression of MEK1EE, a constitutive form of MEK1, activated both hyaluronan synthase expression and hyaluronan production. AG-490, a Jak-2 inhibitor, or LY294002, a PI3K inhibitor, similarly suppressed the augmented production of hyarulonan. Taken together, our results suggest the involvement of multiple signaling pathways, including Ras-dependent and independent ones, in augmented hyaluronan production by v-Src.},
 pages = {101--108},
 title = {Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC},
 volume = {67},
 year = {2005}
}