ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "c726f3b8-2e6f-429c-a620-5e5c24775a42"}, "_deposit": {"id": "5691", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5691"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005691", "sets": ["696"]}, "author_link": ["15134", "15135", "15136", "15137"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-10-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "444", "bibliographicPageStart": "437", "bibliographicVolumeNumber": "238", "bibliographic_titles": [{"bibliographic_title": "Gene", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The Rho family of small GTPases and their associated regulators and targets are essential mediators of diverse morphogenetic events in development. Mammalian Rho‐kinase/ROKα, one of the targets of Rho, has been shown to bind to Rho in GTP-bound form and to phosphorylate the myosin light chain (MLC) and the myosin binding subunit (MBS) of myosin phosphatase, resulting in the activation of myosin. Thus, Rho‐kinase/ROKα has been suggested to play essential roles in the formation of stress fibers and focal adhesions. We have identified the Drosophila homolog of Rho‐kinase/ROKα, DRho‐kinase, which has conserved the basic structural feature of Rho‐kinase/ROKα consisting of the N‐terminal kinase, central coiled-coil and C‐terminal pleckstrin homology (PH) domains. A two‐hybrid analysis demonstrated that DRho‐kinase interacts with the GTP‐bound form of the Drosophila Rho, Drho1, at the conserved Rho-binding site. DRho‐kinase can phosphorylate MLC and MBS, preferable substrates for bovine Rho‐kinase, in vitro. DRho‐kinase is ubiquitously expressed throughout development, in a pattern essentially identical to that of Drho1. These results suggest that DRho‐kinase is an effector of Drho1.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7297"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/S0378-1119(99)00351-0", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0378-1119", "subitem_source_identifier_type": "PISSN"}]}, "item_10_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mizuno, Tomoaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15134", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano, Mutsuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaibuchi, Kozo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Yasuyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15137", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DRho_kinase_final.pdf", "filesize": [{"value": "417.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 417500.0, "url": {"label": "DRho_kinase_final.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/5691/files/DRho_kinase_final.pdf"}, "version_id": "52ab54d5-fd45-45ec-a6d6-4c5343dde905"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Rho effector", "subitem_subject_scheme": "Other"}, {"subitem_subject": "actin cytoskeleton", "subitem_subject_scheme": "Other"}, {"subitem_subject": "morphogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "low stringency PCR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "two-hybrid analysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "in vitro kinase assay", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Identification and characterization of Drosophila homolog of Rho-kinase", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Identification and characterization of Drosophila homolog of Rho-kinase", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["696"], "permalink_uri": "http://hdl.handle.net/2237/7297", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-02-09"}, "publish_date": "2007-02-09", "publish_status": "0", "recid": "5691", "relation": {}, "relation_version_is_last": true, "title": ["Identification and characterization of Drosophila homolog of Rho-kinase"], "weko_shared_id": -1}
  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Identification and characterization of Drosophila homolog of Rho-kinase

http://hdl.handle.net/2237/7297
http://hdl.handle.net/2237/7297
28a6ce2d-1402-441c-bea9-691100844b87
名前 / ファイル ライセンス アクション
DRho_kinase_final.pdf DRho_kinase_final.pdf (417.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-02-09
タイトル
タイトル Identification and characterization of Drosophila homolog of Rho-kinase
言語 en
著者 Mizuno, Tomoaki

× Mizuno, Tomoaki

WEKO 15134

en Mizuno, Tomoaki

Search repository
Amano, Mutsuki

× Amano, Mutsuki

WEKO 15135

en Amano, Mutsuki

Search repository
Kaibuchi, Kozo

× Kaibuchi, Kozo

WEKO 15136

en Kaibuchi, Kozo

Search repository
Nishida, Yasuyoshi

× Nishida, Yasuyoshi

WEKO 15137

en Nishida, Yasuyoshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Rho effector
キーワード
主題Scheme Other
主題 actin cytoskeleton
キーワード
主題Scheme Other
主題 morphogenesis
キーワード
主題Scheme Other
主題 low stringency PCR
キーワード
主題Scheme Other
主題 two-hybrid analysis
キーワード
主題Scheme Other
主題 in vitro kinase assay
抄録
内容記述 The Rho family of small GTPases and their associated regulators and targets are essential mediators of diverse morphogenetic events in development. Mammalian Rho‐kinase/ROKα, one of the targets of Rho, has been shown to bind to Rho in GTP-bound form and to phosphorylate the myosin light chain (MLC) and the myosin binding subunit (MBS) of myosin phosphatase, resulting in the activation of myosin. Thus, Rho‐kinase/ROKα has been suggested to play essential roles in the formation of stress fibers and focal adhesions. We have identified the Drosophila homolog of Rho‐kinase/ROKα, DRho‐kinase, which has conserved the basic structural feature of Rho‐kinase/ROKα consisting of the N‐terminal kinase, central coiled-coil and C‐terminal pleckstrin homology (PH) domains. A two‐hybrid analysis demonstrated that DRho‐kinase interacts with the GTP‐bound form of the Drosophila Rho, Drho1, at the conserved Rho-binding site. DRho‐kinase can phosphorylate MLC and MBS, preferable substrates for bovine Rho‐kinase, in vitro. DRho‐kinase is ubiquitously expressed throughout development, in a pattern essentially identical to that of Drho1. These results suggest that DRho‐kinase is an effector of Drho1.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/S0378-1119(99)00351-0
ISSN
収録物識別子タイプ PISSN
収録物識別子 0378-1119
書誌情報 en : Gene

巻 238, 号 2, p. 437-444, 発行日 1999-10-01
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7297
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 13:05:20.160617
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3