WEKO3
アイテム
{"_buckets": {"deposit": "060ed8cd-4d27-4d9f-855b-2033c0c59ffd"}, "_deposit": {"id": "5828", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5828"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005828", "sets": ["501"]}, "author_link": ["15464", "15465", "15466", "15467", "15468", "15469", "15470", "15471", "15472", "15473", "15474"], "control_number": "5828", "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "630", "bibliographicPageStart": "624", "bibliographicVolumeNumber": "24", "bibliographic_titles": [{"bibliographic_title": "Stem Cells", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Mouse embryonic stem cells (ES cells) are pluripotent and retain the potential to form an organ similar to gut showing spontaneous contractions in vitro. The morphological features and their formation process using the hanging drop method to compose embryoid bodies (EBs) seem to be similar to those in vivo. To determine whether the same molecular mechanisms are involved in the formation process, the expressions of transcription factors regulating endoderm and gut development in the mouse embryo were examined by in situ hybridization and compared to those in vivo. The expressions of gene products were also examined by immunohistochemistry and their co-localization was analyzed with double staining. The results showed that all factors examined, i.e., Sox17, Id2, HNF3β/Foxa2, and GATA4, were expressed in both EBs and the gut-like structures. Moreover, their expression patterns were similar to those in the mouse embryo. EBs, after the hanging drop and before outgrowth, already expressed all factors co-localized with each other at the EB epithelial structures. These findings suggest that the origin of gut-like structure is determined and formed as the epithelial structure in EB during the hanging drop, and they also indicate that the in vitro system using mouse ES cells mimics the development in vivo and should prove useful in the study of molecular mechanisms for endoderm and gut development.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7444"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Alpha Med Press", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1634/stemcells.2005-0344", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1066-5099", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuura, Rie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kogo, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15465", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogaeri, Takunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15466", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15467", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwahara, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15468", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanai, Yoshiakira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15469", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa, Takumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15470", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroiwa, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15471", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto, Toyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Torihashi, Shigeko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鳥橋, 茂子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "15474", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Fig7.pdf", "filesize": [{"value": "79.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 79800.0, "url": {"label": "Fig7.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig7.pdf"}, "version_id": "6fd698ea-cb64-4dc6-834a-4a0966ef41d6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Fig6.pdf", "filesize": [{"value": "50.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 50900.0, "url": {"label": "Fig6.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig6.pdf"}, "version_id": "c004e91c-bc14-4177-8b6f-69e459fec2f0"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Fig5.pdf", "filesize": [{"value": "50.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 50800.0, "url": {"label": "Fig5.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig5.pdf"}, "version_id": "9d7ea3fc-c881-443a-842d-c70c5d0cf282"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 3, "filename": "Fig4.pdf", "filesize": [{"value": "48.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 48500.0, "url": {"label": "Fig4.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig4.pdf"}, "version_id": "3cd4186e-dba4-497b-ad66-f1b6e3484455"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 4, "filename": "Fig3.pdf", "filesize": [{"value": "41.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 41000.0, "url": {"label": "Fig3.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig3.pdf"}, "version_id": "dd1a8fa8-fa27-46b5-8759-10fb8c1de3c3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 5, "filename": "Fig2.pdf", "filesize": [{"value": "47.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 47800.0, "url": {"label": "Fig2.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig2.pdf"}, "version_id": "bf4e2802-833f-41e7-8ba5-29e879bcd68f"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 6, "filename": "Fig1.pdf", "filesize": [{"value": "38.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 38800.0, "url": {"label": "Fig1.pdf", "objectType": "dataset", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Fig1.pdf"}, "version_id": "0b80d0cc-8bce-42a8-9753-6b0d0deab10b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 7, "filename": "Stem_Cells_accepted.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "Stem_Cells_accepted.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/5828/files/Stem_Cells_accepted.pdf"}, "version_id": "a28aa5d4-78bf-40f2-a2a5-479604e57075"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "embryonic stem cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "embryoid body", "subitem_subject_scheme": "Other"}, {"subitem_subject": "transcription factors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastrointestinal motility", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/7444", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-03-07"}, "publish_date": "2007-03-07", "publish_status": "0", "recid": "5828", "relation": {}, "relation_version_is_last": true, "title": ["Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells"], "weko_shared_id": 3}
Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells
http://hdl.handle.net/2237/7444
http://hdl.handle.net/2237/7444a2bd6f67-04df-40a7-9612-210c5c532029
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-03-07 | |||||
タイトル | ||||||
タイトル | Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells | |||||
言語 | en | |||||
著者 |
Matsuura, Rie
× Matsuura, Rie× Kogo, Hiroshi× Ogaeri, Takunori× Miwa, Takashi× Kuwahara, Masaki× Kanai, Yoshiakira× Nakagawa, Takumi× Kuroiwa, Atsushi× Fujimoto, Toyoshi× Torihashi, Shigeko× 鳥橋, 茂子 |
|||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | embryonic stem cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | embryoid body | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcription factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastrointestinal motility | |||||
抄録 | ||||||
内容記述 | Mouse embryonic stem cells (ES cells) are pluripotent and retain the potential to form an organ similar to gut showing spontaneous contractions in vitro. The morphological features and their formation process using the hanging drop method to compose embryoid bodies (EBs) seem to be similar to those in vivo. To determine whether the same molecular mechanisms are involved in the formation process, the expressions of transcription factors regulating endoderm and gut development in the mouse embryo were examined by in situ hybridization and compared to those in vivo. The expressions of gene products were also examined by immunohistochemistry and their co-localization was analyzed with double staining. The results showed that all factors examined, i.e., Sox17, Id2, HNF3β/Foxa2, and GATA4, were expressed in both EBs and the gut-like structures. Moreover, their expression patterns were similar to those in the mouse embryo. EBs, after the hanging drop and before outgrowth, already expressed all factors co-localized with each other at the EB epithelial structures. These findings suggest that the origin of gut-like structure is determined and formed as the epithelial structure in EB during the hanging drop, and they also indicate that the in vitro system using mouse ES cells mimics the development in vivo and should prove useful in the study of molecular mechanisms for endoderm and gut development. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Alpha Med Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1634/stemcells.2005-0344 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1066-5099 | |||||
書誌情報 |
en : Stem Cells 巻 24, 号 3, p. 624-630, 発行日 2006-03 |
|||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7444 | |||||
識別子タイプ | HDL |