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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells

http://hdl.handle.net/2237/7444
http://hdl.handle.net/2237/7444
a2bd6f67-04df-40a7-9612-210c5c532029
名前 / ファイル ライセンス アクション
Fig7.pdf Fig7.pdf (79.8 kB)
Fig6.pdf Fig6.pdf (50.9 kB)
Fig5.pdf Fig5.pdf (50.8 kB)
Fig4.pdf Fig4.pdf (48.5 kB)
Fig3.pdf Fig3.pdf (41.0 kB)
Fig2.pdf Fig2.pdf (47.8 kB)
Fig1.pdf Fig1.pdf (38.8 kB)
Stem_Cells_accepted.pdf Stem_Cells_accepted.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-03-07
タイトル
タイトル Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells
言語 en
著者 Matsuura, Rie

× Matsuura, Rie

WEKO 15464

en Matsuura, Rie

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Kogo, Hiroshi

× Kogo, Hiroshi

WEKO 15465

en Kogo, Hiroshi

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Ogaeri, Takunori

× Ogaeri, Takunori

WEKO 15466

en Ogaeri, Takunori

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Miwa, Takashi

× Miwa, Takashi

WEKO 15467

en Miwa, Takashi

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Kuwahara, Masaki

× Kuwahara, Masaki

WEKO 15468

en Kuwahara, Masaki

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Kanai, Yoshiakira

× Kanai, Yoshiakira

WEKO 15469

en Kanai, Yoshiakira

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Nakagawa, Takumi

× Nakagawa, Takumi

WEKO 15470

en Nakagawa, Takumi

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Kuroiwa, Atsushi

× Kuroiwa, Atsushi

WEKO 15471

en Kuroiwa, Atsushi

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Fujimoto, Toyoshi

× Fujimoto, Toyoshi

WEKO 15472

en Fujimoto, Toyoshi

Search repository
Torihashi, Shigeko

× Torihashi, Shigeko

WEKO 15473

en Torihashi, Shigeko

Search repository
鳥橋, 茂子

× 鳥橋, 茂子

WEKO 15474

ja 鳥橋, 茂子

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 embryonic stem cell
キーワード
主題Scheme Other
主題 embryoid body
キーワード
主題Scheme Other
主題 transcription factors
キーワード
主題Scheme Other
主題 development
キーワード
主題Scheme Other
主題 gastrointestinal motility
抄録
内容記述 Mouse embryonic stem cells (ES cells) are pluripotent and retain the potential to form an organ similar to gut showing spontaneous contractions in vitro. The morphological features and their formation process using the hanging drop method to compose embryoid bodies (EBs) seem to be similar to those in vivo. To determine whether the same molecular mechanisms are involved in the formation process, the expressions of transcription factors regulating endoderm and gut development in the mouse embryo were examined by in situ hybridization and compared to those in vivo. The expressions of gene products were also examined by immunohistochemistry and their co-localization was analyzed with double staining. The results showed that all factors examined, i.e., Sox17, Id2, HNF3β/Foxa2, and GATA4, were expressed in both EBs and the gut-like structures. Moreover, their expression patterns were similar to those in the mouse embryo. EBs, after the hanging drop and before outgrowth, already expressed all factors co-localized with each other at the EB epithelial structures. These findings suggest that the origin of gut-like structure is determined and formed as the epithelial structure in EB during the hanging drop, and they also indicate that the in vitro system using mouse ES cells mimics the development in vivo and should prove useful in the study of molecular mechanisms for endoderm and gut development.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Alpha Med Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1634/stemcells.2005-0344
ISSN
収録物識別子タイプ PISSN
収録物識別子 1066-5099
書誌情報 en : Stem Cells

巻 24, 号 3, p. 624-630, 発行日 2006-03
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7444
識別子タイプ HDL
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