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ICC are located in the proximity with enteric neurons and connected with each other to make cellular network. One of their functions is pacemakers of the spontaneous smooth muscle contractions. They generate electrical rhythmicity as slow waves and propagate to smooth muscles. ICC show oscillations of cytosolic calcium linked to slow waves. ICC also mediate neurotransmission from enteric neurons, and regulate excitatory and inhibitory neurotransmissions. They express several receptors of neurotransmitters. 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