@article{oai:nagoya.repo.nii.ac.jp:00005840,
 author = {鳥橋, 茂子 and Torihashi, Shigeko},
 issue = {Suppl.2},
 journal = {電子顕微鏡},
 month = {},
 note = {Embryonic stem (ES) cells have pluripotency and give rise to many cell types and tissues including representatives of all three germ layers in the embryo. We previously reported that mouse ES cells formed contracting gut-like organs from embryoid bodies (EBs) (Stem Cells 20:41-49,2002). These gut-like structures contracted spontaneously, and had large lumens surrounded by three layers, i.e., epithelium, lamina propria and muscularis. Ganglia were scattered along the periphery, and interstitial cells of Cajal (ICC) were distributed among the smooth muscle cells. In the present study, to determine whether they can be a model of gut organogenesis, we investigated the formation process of the gut-like structures in comparison with embryonic gut development. As a result, we found that the fundamental process of formation in vitro was similar to embryonic gut development in vivo. The result indicates that the gut- like structure is a useful tool not only for developmental study to determine the factors that induce gut organogenesis, but also for studies of enteric neuron and ICC development.},
 pages = {71--74},
 title = {マウスES細胞を用いた消化管様構造の形成},
 volume = {38},
 year = {2003}
}