@article{oai:nagoya.repo.nii.ac.jp:00005949,
 author = {Kobayashi, Hironobu and Imai, Tsuneo and Kambe, Fukushi and Mirza, Rusella and Seo, Hisao},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Although the regulation of steroidogenesis in adrenal fasciculate and reticularis is stimulated by adrenocorticotrophic hormone (ACTH), its role on the proliferation of adrenocortical call is not established. We thus investigated the effect of ACTH on the proliferation of adrenocortical cells by analyzing the expression of proliferating cell nuclear antigen (PCNA). Endogeneous secretion of ACTH was inhibited by treatment with dexamethasone for 5 days. At intervals after ACTH treatment, homogenate of the adrenal gland was subjected to Western blot analysis. PCNA expression was detected in control rat without any treatment. Dexamethasone administration for 5 days resulted in the reduction of PCNA expression. ACTH administration to the dexamethasone treated rats increased PCNA expression at 24 hr. It is thus demonstrated that ACTH increases cellular proliferation in adrenal cortex., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {20--21},
 title = {Effect of ACTH on the Proliferation of the Rat Adrenal Gland},
 volume = {47},
 year = {2003}
}