{"_buckets": {"deposit": "0217ce6a-31d4-41f8-b784-3f25cf078e02"}, "_deposit": {"id": "5959", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5959"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005959", "sets": []}, "author_link": ["15866", "15867", "15868", "15869", "15870", "15871", "15872", "15873"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "41", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Antiarrhythmic effects of long-term amiodarone is supposed to be mediated in part by cardio-selective hypothyroidism, but the issue remains controversial. We examined mRNA expression of sacroplasmic reticulum Ca^2+-ATPase(SERCA2) by Northern blot analysis in rats treated with amiodarone (60mg/kg/day, 4 weeks) or dronedarone (60mg/kg/day, 4 weeks). SERCA2 mRNA level in ventricular muscle was significantly decreased in hypothyroid rats by 38±9%(p\u003c0.05, n=4), whereas increased in hyperthyroid rats by 39±19%(p\u003c0.05, n=4) compared with control (euthyroid) rats. Amiodarone treatment caused a slight decrease in SERCA2 mRNA(by 20±13%, n=4), whereas dronedarone treatment caused a slight increase (by 19±23%, n=3), although the changes did not reach statistical significance. Amiodarone and dronedarone have different effects on the gene transcription of SERCA2 in the heart, suggesting their different thyroid hormone-mediated actions.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7573"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.47.39", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0287-0517", "subitem_source_identifier_type": "PISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shi, Rong-qian", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15866", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lee, Jong-Kook", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15867", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Yoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15868", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Liyan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15869", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, Keiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15870", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kambe, Fukushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15871", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Yoshiharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15872", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15873", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39-41.pdf", "filesize": [{"value": "295.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 295800.0, "url": {"label": "39-41.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/5959/files/39-41.pdf"}, "version_id": "b0c73a51-fac1-4ab7-b463-d992ba868cf6"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "amiodarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dronedarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SERCA2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["737"], "permalink_uri": "https://doi.org/10.18999/envm.47.39", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-05"}, "publish_date": "2007-04-05", "publish_status": "0", "recid": "5959", "relation": {}, "relation_version_is_last": true, "title": ["Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene"], "weko_shared_id": -1}