{"_buckets": {"deposit": "0217ce6a-31d4-41f8-b784-3f25cf078e02"}, "_deposit": {"id": "5959", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5959"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005959"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "41", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Antiarrhythmic effects of long-term amiodarone is supposed to be mediated in part by cardio-selective hypothyroidism, but the issue remains controversial. We examined mRNA expression of sacroplasmic reticulum Ca^2+-ATPase(SERCA2) by Northern blot analysis in rats treated with amiodarone (60mg/kg/day, 4 weeks) or dronedarone (60mg/kg/day, 4 weeks). SERCA2 mRNA level in ventricular muscle was significantly decreased in hypothyroid rats by 38\u00b19%(p\u003c0.05, n=4), whereas increased in hyperthyroid rats by 39\u00b119%(p\u003c0.05, n=4) compared with control (euthyroid) rats. Amiodarone treatment caused a slight decrease in SERCA2 mRNA(by 20\u00b113%, n=4), whereas dronedarone treatment caused a slight increase (by 19\u00b123%, n=3), although the changes did not reach statistical significance. Amiodarone and dronedarone have different effects on the gene transcription of SERCA2 in the heart, suggesting their different thyroid hormone-mediated actions.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7573"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.47.39", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of 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"nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Liyan"}], "nameIdentifiers": [{"nameIdentifier": "15869", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, Keiko"}], "nameIdentifiers": [{"nameIdentifier": "15870", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kambe, Fukushi"}], "nameIdentifiers": [{"nameIdentifier": "15871", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Yoshiharu"}], "nameIdentifiers": [{"nameIdentifier": "15872", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo"}], "nameIdentifiers": [{"nameIdentifier": "15873", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39-41.pdf", "filesize": [{"value": "295.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 295800.0, "url": {"label": "39-41.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/5959/files/39-41.pdf"}, "version_id": "b0c73a51-fac1-4ab7-b463-d992ba868cf6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "amiodarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dronedarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SERCA2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene"}]}, "item_type_id": "9", "owner": "1", "path": ["329/333/334/737"], "permalink_uri": "https://doi.org/10.18999/envm.47.39", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-04-05"}, "publish_date": "2007-04-05", "publish_status": "0", "recid": "5959", "relation": {}, "relation_version_is_last": true, "title": ["Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene"], "weko_shared_id": null}