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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene

https://doi.org/10.18999/envm.47.39
https://doi.org/10.18999/envm.47.39
0c935270-3dd0-4873-bc68-1881316a4523
名前 / ファイル ライセンス アクション
39-41.pdf 39-41.pdf (295.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-05
タイトル
タイトル Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene
言語 en
著者 Shi, Rong-qian

× Shi, Rong-qian

WEKO 15866

en Shi, Rong-qian

Search repository
Lee, Jong-Kook

× Lee, Jong-Kook

WEKO 15867

en Lee, Jong-Kook

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Takeuchi, Yoko

× Takeuchi, Yoko

WEKO 15868

en Takeuchi, Yoko

Search repository
Zhang, Liyan

× Zhang, Liyan

WEKO 15869

en Zhang, Liyan

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Miwa, Keiko

× Miwa, Keiko

WEKO 15870

en Miwa, Keiko

Search repository
Kambe, Fukushi

× Kambe, Fukushi

WEKO 15871

en Kambe, Fukushi

Search repository
Murata, Yoshiharu

× Murata, Yoshiharu

WEKO 15872

en Murata, Yoshiharu

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Kodama, Itsuo

× Kodama, Itsuo

WEKO 15873

en Kodama, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 amiodarone
キーワード
主題Scheme Other
主題 dronedarone
キーワード
主題Scheme Other
主題 thyroid hormone
キーワード
主題Scheme Other
主題 SERCA2
抄録
内容記述 Antiarrhythmic effects of long-term amiodarone is supposed to be mediated in part by cardio-selective hypothyroidism, but the issue remains controversial. We examined mRNA expression of sacroplasmic reticulum Ca^2+-ATPase(SERCA2) by Northern blot analysis in rats treated with amiodarone (60mg/kg/day, 4 weeks) or dronedarone (60mg/kg/day, 4 weeks). SERCA2 mRNA level in ventricular muscle was significantly decreased in hypothyroid rats by 38±9%(p<0.05, n=4), whereas increased in hyperthyroid rats by 39±19%(p<0.05, n=4) compared with control (euthyroid) rats. Amiodarone treatment caused a slight decrease in SERCA2 mRNA(by 20±13%, n=4), whereas dronedarone treatment caused a slight increase (by 19±23%, n=3), although the changes did not reach statistical significance. Amiodarone and dronedarone have different effects on the gene transcription of SERCA2 in the heart, suggesting their different thyroid hormone-mediated actions.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.39
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 39-41, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7573
識別子タイプ HDL
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