@article{oai:nagoya.repo.nii.ac.jp:00005959, author = {Shi, Rong-qian and Lee, Jong-Kook and Takeuchi, Yoko and Zhang, Liyan and Miwa, Keiko and Kambe, Fukushi and Murata, Yoshiharu and Kodama, Itsuo}, journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University}, month = {Dec}, note = {Antiarrhythmic effects of long-term amiodarone is supposed to be mediated in part by cardio-selective hypothyroidism, but the issue remains controversial. We examined mRNA expression of sacroplasmic reticulum Ca^2+-ATPase(SERCA2) by Northern blot analysis in rats treated with amiodarone (60mg/kg/day, 4 weeks) or dronedarone (60mg/kg/day, 4 weeks). SERCA2 mRNA level in ventricular muscle was significantly decreased in hypothyroid rats by 38±9%(p<0.05, n=4), whereas increased in hyperthyroid rats by 39±19%(p<0.05, n=4) compared with control (euthyroid) rats. Amiodarone treatment caused a slight decrease in SERCA2 mRNA(by 20±13%, n=4), whereas dronedarone treatment caused a slight increase (by 19±23%, n=3), although the changes did not reach statistical significance. Amiodarone and dronedarone have different effects on the gene transcription of SERCA2 in the heart, suggesting their different thyroid hormone-mediated actions., 研究所で電子化したコンテンツを使用している。}, pages = {39--41}, title = {Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene}, volume = {47}, year = {2003} }