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Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels
https://doi.org/10.18999/envm.47.48
https://doi.org/10.18999/envm.47.48db68bc22-0552-4062-8b9a-5e7993e78533
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-06 | |||||
タイトル | ||||||
タイトル | Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels | |||||
言語 | en | |||||
著者 |
Shimizu, Atsuya
× Shimizu, Atsuya× Niwa, Ryoko× Lu, Zhibo× Honjo, Haruo× Kamiya, Kaichiro |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dronedarone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amiodarone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HERG channel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | KCNQ1/KCNE1 channels | |||||
抄録 | ||||||
内容記述 | Dronedarone, a noniodinated and methanesulfonanilide derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic agent alternative to amiodarone. However, effects of this drug on I_<Kr> and I_<Ks> channels, two major cardiac repolarizing potassium channels, had not been determined yet. <br/>To clarify the effects on I_<Kr> and I_<Ks>, we studied the effects of dronedarone on HERG channels and KCNQ1/KCNE1 channels heterologously expressed in Xenopus Oocytes by 2-electrodes voltage clamp technique. Because I_<Kr> channel is coded by HERG gene, and I_<Ks> is coded by co-expression of both KCNQ 1 and KCNE1 genes.<br/> Dronedarone potently blocked both HERG channel (IC_<50> : 3.8±1.0μM, 0 mV, n=3) and KCNQ1/KCNE1 channels (IC_<50> : 19.1±2.1μM, 0 mV, n=2). Amiodarone, a structurally similar compound of dronedarone, had already reported not to block KCNQ1/KCNE1 channels. These findings together with previous reports suggest that 1) dronedarone potently inhibits both HERG channels and KCNQ1/ KCNE1 channels. 2) Insertion of methanesulfonanilide compound to dronedarone might result in an inhibitory action on KCNQ1/KCNE1 channels. 3) Dronedarone might be a potential antiarrhythmic drug. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.47.48 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0287-0517 | |||||
書誌情報 |
en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 47, p. 48-50, 発行日 2003-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7585 | |||||
識別子タイプ | HDL |