{"_buckets": {"deposit": "4400a982-8e06-4e27-8f54-2c3e66123b0e"}, "_deposit": {"id": "5965", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5965"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005965"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "50", "bibliographicPageStart": "48", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Dronedarone, a noniodinated and methanesulfonanilide derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic agent alternative to amiodarone. However, effects of this drug on I_\u003cKr\u003e and I_\u003cKs\u003e channels, two major cardiac repolarizing potassium channels, had not been determined yet. \nTo clarify the effects on I_\u003cKr\u003e and I_\u003cKs\u003e, we studied the effects of dronedarone on HERG channels and KCNQ1/KCNE1 channels heterologously expressed in Xenopus Oocytes by 2-electrodes voltage clamp technique. Because I_\u003cKr\u003e channel is coded by HERG gene, and I_\u003cKs\u003e  is coded by co-expression of both KCNQ 1 and KCNE1 genes.\n Dronedarone potently blocked both HERG channel (IC_\u003c50\u003e : 3.8\u00b11.0\u03bcM, 0 mV, n=3) and KCNQ1/KCNE1 channels (IC_\u003c50\u003e : 19.1\u00b12.1\u03bcM, 0 mV, n=2). Amiodarone, a structurally similar compound of dronedarone, had already reported not to block KCNQ1/KCNE1 channels. These findings together with previous reports suggest that 1) dronedarone potently inhibits both HERG channels and KCNQ1/ KCNE1 channels. 2) Insertion of methanesulfonanilide compound to dronedarone might result in an inhibitory action on KCNQ1/KCNE1 channels. 3) Dronedarone might be a potential  antiarrhythmic drug.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u56fd\u7acb\u60c5\u5831\u5b66\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7585"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.47.48", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0287-0517", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimizu, Atsuya"}], "nameIdentifiers": [{"nameIdentifier": "15891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Ryoko"}], "nameIdentifiers": [{"nameIdentifier": "15892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Zhibo"}], "nameIdentifiers": [{"nameIdentifier": "15893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honjo, Haruo"}], "nameIdentifiers": [{"nameIdentifier": "15894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro"}], "nameIdentifiers": [{"nameIdentifier": "15895", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "48-50.pdf", "filesize": [{"value": "294.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 294700.0, "url": {"label": "48-50.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/5965/files/48-50.pdf"}, "version_id": "e1082287-e848-4652-92e5-44f558f88766"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Dronedarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Amiodarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HERG channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KCNQ1/KCNE1 channels", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels"}]}, "item_type_id": "9", "owner": "1", "path": ["329/333/334/737"], "permalink_uri": "https://doi.org/10.18999/envm.47.48", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-04-06"}, "publish_date": "2007-04-06", "publish_status": "0", "recid": "5965", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels"], "weko_shared_id": null}