ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "4400a982-8e06-4e27-8f54-2c3e66123b0e"}, "_deposit": {"id": "5965", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5965"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005965", "sets": []}, "author_link": ["15891", "15892", "15893", "15894", "15895"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "50", "bibliographicPageStart": "48", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Dronedarone, a noniodinated and methanesulfonanilide derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic agent alternative to amiodarone. However, effects of this drug on I_\u003cKr\u003e and I_\u003cKs\u003e channels, two major cardiac repolarizing potassium channels, had not been determined yet. \u003cbr/\u003eTo clarify the effects on I_\u003cKr\u003e and I_\u003cKs\u003e, we studied the effects of dronedarone on HERG channels and KCNQ1/KCNE1 channels heterologously expressed in Xenopus Oocytes by 2-electrodes voltage clamp technique. Because I_\u003cKr\u003e channel is coded by HERG gene, and I_\u003cKs\u003e  is coded by co-expression of both KCNQ 1 and KCNE1 genes.\u003cbr/\u003e Dronedarone potently blocked both HERG channel (IC_\u003c50\u003e : 3.8±1.0μM, 0 mV, n=3) and KCNQ1/KCNE1 channels (IC_\u003c50\u003e : 19.1±2.1μM, 0 mV, n=2). Amiodarone, a structurally similar compound of dronedarone, had already reported not to block KCNQ1/KCNE1 channels. These findings together with previous reports suggest that 1) dronedarone potently inhibits both HERG channels and KCNQ1/ KCNE1 channels. 2) Insertion of methanesulfonanilide compound to dronedarone might result in an inhibitory action on KCNQ1/KCNE1 channels. 3) Dronedarone might be a potential  antiarrhythmic drug.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7585"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.47.48", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0287-0517", "subitem_source_identifier_type": "PISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimizu, Atsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Ryoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Zhibo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honjo, Haruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "15895", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "48-50.pdf", "filesize": [{"value": "294.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 294700.0, "url": {"label": "48-50.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/5965/files/48-50.pdf"}, "version_id": "e1082287-e848-4652-92e5-44f558f88766"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Dronedarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Amiodarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HERG channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KCNQ1/KCNE1 channels", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["737"], "permalink_uri": "https://doi.org/10.18999/envm.47.48", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-06"}, "publish_date": "2007-04-06", "publish_status": "0", "recid": "5965", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels"], "weko_shared_id": -1}
  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels

https://doi.org/10.18999/envm.47.48
https://doi.org/10.18999/envm.47.48
db68bc22-0552-4062-8b9a-5e7993e78533
名前 / ファイル ライセンス アクション
48-50.pdf 48-50.pdf (294.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-06
タイトル
タイトル Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels
言語 en
著者 Shimizu, Atsuya

× Shimizu, Atsuya

WEKO 15891

en Shimizu, Atsuya

Search repository
Niwa, Ryoko

× Niwa, Ryoko

WEKO 15892

en Niwa, Ryoko

Search repository
Lu, Zhibo

× Lu, Zhibo

WEKO 15893

en Lu, Zhibo

Search repository
Honjo, Haruo

× Honjo, Haruo

WEKO 15894

en Honjo, Haruo

Search repository
Kamiya, Kaichiro

× Kamiya, Kaichiro

WEKO 15895

en Kamiya, Kaichiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Dronedarone
キーワード
主題Scheme Other
主題 Amiodarone
キーワード
主題Scheme Other
主題 HERG channel
キーワード
主題Scheme Other
主題 KCNQ1/KCNE1 channels
抄録
内容記述 Dronedarone, a noniodinated and methanesulfonanilide derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic agent alternative to amiodarone. However, effects of this drug on I_<Kr> and I_<Ks> channels, two major cardiac repolarizing potassium channels, had not been determined yet. <br/>To clarify the effects on I_<Kr> and I_<Ks>, we studied the effects of dronedarone on HERG channels and KCNQ1/KCNE1 channels heterologously expressed in Xenopus Oocytes by 2-electrodes voltage clamp technique. Because I_<Kr> channel is coded by HERG gene, and I_<Ks> is coded by co-expression of both KCNQ 1 and KCNE1 genes.<br/> Dronedarone potently blocked both HERG channel (IC_<50> : 3.8±1.0μM, 0 mV, n=3) and KCNQ1/KCNE1 channels (IC_<50> : 19.1±2.1μM, 0 mV, n=2). Amiodarone, a structurally similar compound of dronedarone, had already reported not to block KCNQ1/KCNE1 channels. These findings together with previous reports suggest that 1) dronedarone potently inhibits both HERG channels and KCNQ1/ KCNE1 channels. 2) Insertion of methanesulfonanilide compound to dronedarone might result in an inhibitory action on KCNQ1/KCNE1 channels. 3) Dronedarone might be a potential antiarrhythmic drug.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.48
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 48-50, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7585
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 20:19:19.302553
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3