@article{oai:nagoya.repo.nii.ac.jp:00005965,
 author = {Shimizu, Atsuya and Niwa, Ryoko and Lu, Zhibo and Honjo, Haruo and Kamiya, Kaichiro},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Dronedarone, a noniodinated and methanesulfonanilide derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic agent alternative to amiodarone. However, effects of this drug on I_<Kr> and I_<Ks> channels, two major cardiac repolarizing potassium channels, had not been determined yet. <br/>To clarify the effects on I_<Kr> and I_<Ks>, we studied the effects of dronedarone on HERG channels and KCNQ1/KCNE1 channels heterologously expressed in Xenopus Oocytes by 2-electrodes voltage clamp technique. Because I_<Kr> channel is coded by HERG gene, and I_<Ks>  is coded by co-expression of both KCNQ 1 and KCNE1 genes.<br/> Dronedarone potently blocked both HERG channel (IC_<50> : 3.8±1.0μM, 0 mV, n=3) and KCNQ1/KCNE1 channels (IC_<50> : 19.1±2.1μM, 0 mV, n=2). Amiodarone, a structurally similar compound of dronedarone, had already reported not to block KCNQ1/KCNE1 channels. These findings together with previous reports suggest that 1) dronedarone potently inhibits both HERG channels and KCNQ1/ KCNE1 channels. 2) Insertion of methanesulfonanilide compound to dronedarone might result in an inhibitory action on KCNQ1/KCNE1 channels. 3) Dronedarone might be a potential  antiarrhythmic drug., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {48--50},
 title = {Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels},
 volume = {47},
 year = {2003}
}