@article{oai:nagoya.repo.nii.ac.jp:00005970,
 author = {Niwa, Ryoko and Shimizu, Atsuya and Lu, Zhibo and Honjo, Haruo and Kamiya, Kaichiro},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage-dependent block by amiodarone, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, amiodarone caused a concentration-dependent inhibition of D540K HERG current with IC_<50> of 15±5 μM(n=4). At-150 mV, inhibition by amiodarone was almost abolished (IC_<50> :>10 mM, n=4). These results suggest that binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {51--52},
 title = {Voltage-Dependent Effects of Amiodarone on D540K HERG Channels},
 volume = {47},
 year = {2003}
}