{"created":"2021-03-01T06:12:33.488464+00:00","id":5970,"links":{},"metadata":{"_buckets":{"deposit":"ec4bdda2-d2d4-4544-8c2d-effa8f506eb7"},"_deposit":{"id":"5970","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5970"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00005970","sets":["329:333:334:737"]},"author_link":["15904","15905","15906","15907","15908"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"52","bibliographicPageStart":"51","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage-dependent block by amiodarone, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, amiodarone caused a concentration-dependent inhibition of D540K HERG current with IC_<50> of 15±5 μM(n=4). At-150 mV, inhibition by amiodarone was almost abolished (IC_<50> :>10 mM, n=4). These results suggest that binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/7587"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.47.51","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0287-0517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Niwa, Ryoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Atsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Zhibo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honjo, Haruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Kaichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15908","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"51-52.pdf","filesize":[{"value":"202.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"51-52.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/5970/files/51-52.pdf"},"version_id":"183ee763-545a-4b7f-a4ba-ca26c9adcfce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"amiodarone","subitem_subject_scheme":"Other"},{"subitem_subject":"potassium channels","subitem_subject_scheme":"Other"},{"subitem_subject":"arrhythmia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Voltage-Dependent Effects of Amiodarone on D540K HERG Channels","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Voltage-Dependent Effects of Amiodarone on D540K HERG Channels","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["737"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-06"},"publish_date":"2007-04-06","publish_status":"0","recid":"5970","relation_version_is_last":true,"title":["Voltage-Dependent Effects of Amiodarone on D540K HERG Channels"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T06:20:30.603756+00:00"}