@article{oai:nagoya.repo.nii.ac.jp:00005976,
 author = {Oguma, Tetsuya and Kume, Hiroaki and Ishikawa, Takayuki and Ito, Satoru and Kondo, Masashi and Honjo, Haruo and Kamiya, Kaichiro and Shimokata, Kaoru},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {To determine whether a reduction in the sensitivity to Ca^2+ is involved in relaxation by β-adrenergic receptor agonists, we examined correlation between force generation and intracellular Ca^2+ concentration in the inhibitory effects of  isoproterenol (ISO) on methacholine (MCh)-induced contraction. Fura-2 was loaded in tracheal smooth muscle of guinea pigs and tension and fluorescence ratio F_<340>/F_<380> as an index of intracellular Ca^2+ concentration were recorded simultaneously. Addition of 0.3 μM ISO caused an inhibition in 1 μM MCh-induced contraction and a reduction in intracellular Ca^2+ concentration. The reduction in intracellular Ca^2+ concentration was, however, much smaller than that of tension. In conclusion, Ca^2+ sensitivity in addition to Ca^2+ influx plays an important role in β-adrenergic action in airway smooth muscle., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {59--61},
 title = {The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle},
 volume = {47},
 year = {2003}
}