{"created":"2021-03-01T06:12:33.862422+00:00","id":5976,"links":{},"metadata":{"_buckets":{"deposit":"b2200ef1-ce6d-4c63-9d25-c8dacabc067e"},"_deposit":{"id":"5976","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5976"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00005976","sets":["329:333:334:737"]},"author_link":["15938","15939","15940","15941","15942","15943","15944","15945"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"61","bibliographicPageStart":"59","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine whether a reduction in the sensitivity to Ca^2+ is involved in relaxation by β-adrenergic receptor agonists, we examined correlation between force generation and intracellular Ca^2+ concentration in the inhibitory effects of  isoproterenol (ISO) on methacholine (MCh)-induced contraction. Fura-2 was loaded in tracheal smooth muscle of guinea pigs and tension and fluorescence ratio F_<340>/F_<380> as an index of intracellular Ca^2+ concentration were recorded simultaneously. Addition of 0.3 μM ISO caused an inhibition in 1 μM MCh-induced contraction and a reduction in intracellular Ca^2+ concentration. The reduction in intracellular Ca^2+ concentration was, however, much smaller than that of tension. In conclusion, Ca^2+ sensitivity in addition to Ca^2+ influx plays an important role in β-adrenergic action in airway smooth muscle.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/7593"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.47.59","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0287-0517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oguma, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kume, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honjo, Haruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Kaichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokata, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15945","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"59-61.pdf","filesize":[{"value":"227.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"59-61.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/5976/files/59-61.pdf"},"version_id":"492b3cfc-158b-40e4-8879-c4b46529cdaa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"calcium sensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"beta-adrenergic agonists","subitem_subject_scheme":"Other"},{"subitem_subject":"smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"isoproterenol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["737"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-06"},"publish_date":"2007-04-06","publish_status":"0","recid":"5976","relation_version_is_last":true,"title":["The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T06:20:35.157847+00:00"}