@article{oai:nagoya.repo.nii.ac.jp:00005978, author = {Nakagawa, Harumichi and Yamazaki, Masatoshi and Nihei, Motoki and Niwa, Ryoko and Arafune, Tatsuhiko and Mishima, Akira and Nashimoto, Shiho and Shibata, Nitaro and Honjo, Haruo and Sakuma, Ichiro and Kamiya, Kaichiro and Kodama, Itsuo}, journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University}, month = {Dec}, note = {It is known that electric shocks create a characteristic pattern of polarization (“virtual electrode polarization”) in the myocardium but its roles on post-shock excitations remain to be clarified. We have optically mapped electrical activity of the left ventricular subepicardial layer of Langendorff-perfused rabbit hearts endocardialy frozen. Monophasic anodal and cathodal shocks were applied during the plateau or repolarization phase of the action potential. Electric shocks (20V, 10 ms) resulted in a “dog-bone”pattern of polarization around the stimulation electrode and withdrawl of the shocks were followed by "break excitations". Spread of the break excitations were partially blocked by refractory of the preceding excitation, and slow cunduction around the functional line of block initiated reentrant excitations. These results suggest that break excitations arising from the virtual electrode polarization combined with spatial heterogeneity in repolarization of the preceding excitation play important roles in the genesis of post-shock reentrant activities., 国立情報学研究所で電子化したコンテンツを使用している。}, pages = {62--65}, title = {Virtual Electrode Polarization-Induced Reentrant Activity}, volume = {47}, year = {2003} }