@article{oai:nagoya.repo.nii.ac.jp:00005980,
 author = {Yamazaki, Masatoshi and Honjo, Haruo and Osaka, Toshiyuki and Yokoyama, Eriko and Ito, Atsushi and Kodama, Itsuo},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Recent animal experiments and computer modeling have suggested that cardiac tissues showing steep slope (>1) of action potential duration (APD) restitution would provide a dynamic instability of refractoriness causing a wave break, which is required for the genesis of polymorphic ventricular tachycardia or ventricular fibrillation. However, much remains to be clarified as to the APD restitution kinetics in the normal ventricular myocardium of humans. Monophasic action potentials were recorded from the right ventricular apex and outflow tract in five patients who had no ventricular tachyarrhythmias or structural heart disease. APD restitution kinetics was estimated by a standard S1-S2 protocol. The APD restitution curve was constructed by plotting APD_<90> for each premature stimulus (S2) as a parameter of the preceding diastolic interval. The average values of slope_<max> of  APD_<90> for each premature stimulus (S2) as a parameter of the preceding diastolic interval. The average values of slope_<max> of APD restitution curve were 0.44±0.09 in RVA and 0.49±0.10 in RVOT. The slope_<max> did not exceed 1.0 at any recording sites. These results suggest that normal ventricular muscle in humans have minimal repolarization instability initiating wave break., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {66--68},
 title = {Restitution Kinetics of Ventricular Action Potential Duration In the Human Heart},
 volume = {47},
 year = {2003}
}