@article{oai:nagoya.repo.nii.ac.jp:00005983,
 author = {Ohuchi, Katsuhiro and Fukui, Yasuhiro and Sakuma, Ichiro and Shibata, Nitaro and Honjo, Haruo and Takatani, Setsuo and Kodama, Itsuo},
 journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {The shock intensity-and phase-dependence of high-intensity DC stimulation aftereffects was studied by using Luo-Rudy’s dynamic action potential model. Shock-induced transient rupture (electroporation) of the cell membrane was represented by incorporation of non-selective ionic pores. Application of DC shocks during the plateau phase caused a prolongation of the action potential. Diastolic phase shocks resulted in an activation of action potential with similar delay in repolarization. Oscillatory membrane potentials and single or multiple spontaneous excitations were induced by DC shocks with intermediate intensity and these were accompanied by activation of L-type calcium current during the plateau phase. These results are consistent with observations in animal experiments. The Luo-Rudy’s dynamic action potential model with reversible electroporation-mediated pores may provide useful tools to investigate membrane potential changes and underlying ionic mechanisms following electrical shocks., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {69--71},
 title = {Computer Simulation Analysis of Shock Intensity - and Phase - Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle},
 volume = {47},
 year = {2003}
}