@article{oai:nagoya.repo.nii.ac.jp:00005985, author = {Arafune, Tatsuhiko and Mishima, Akira and Sakuma, Ichiro and Inada, Hiroshi and Shibata, Nitaro and Nakagawa, Harumichi and Yamazaki, Masatoshi and Honjo, Haruo and Kodama, Itsuo}, journal = {Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University}, month = {Dec}, note = {A new optical mapping system and micro electrodes for recording cardiac excitation propagation from isolated hearts was developed and used in experiments to study the effects of DC defibrillation stimulation induced Virtual Electrode Polarization. Isolated rabbit hearts stained with the voltage-sensitive dye, di-4-ANEPPS, ware illuminated by high luminance bluish-green LED. The emitted fluorescence was cut off lower wavelength than 600 [nm] and captured by high-speed digital video camera (Fastcam40K, Photron). The recorded image was transferred PC and digital image processed. Application of anodal/cathodal point stimulation during resting potential phase resulted in make-excitation derived from virtual electrode and excitation wave front propagated. However, point stimulus during plateu phase induced break-excitation from virtual anode/cathode and some cases of particular coupling interval spiral excitation started from the edge of break-excitation and became reentry. The same mechanism of virtual electrode-induced spiral reentry was observed at point stimulation during ventricular tachycardia(VT). Possible mechanisms of the ventricular fibrillation (VF) starts from defibrillation failure are discussed., 国立情報学研究所で電子化したコンテンツを使用している。}, pages = {72--75}, title = {Virtual Electrode-induced Spiral Reentry in Ventricular Myocardium Perfused in-vitro}, volume = {47}, year = {2003} }