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  1. A500 情報学部/情報学研究科・情報文化学部・情報科学研究科
  2. A500b 紀要
  3. 情報文化研究
  4. 13

小頭症ラットの海馬神経回路の生後発達異常

https://doi.org/10.18999/stuis.13.111
5450ceaa-dbff-4e37-9179-f743bf83db4a
名前 / ファイル ライセンス アクション
inf13_111.pdf inf13_111.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-11
タイトル
タイトル 小頭症ラットの海馬神経回路の生後発達異常
その他のタイトル
その他のタイトル Developmental Abnormalities in Neural Circuits in the Hippocampus of Infant Rats with Methylazoxymethanol-induced Microcephaly
著者 中村, 江里

× 中村, 江里

WEKO 16543

中村, 江里

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Nakamura, Eri

× Nakamura, Eri

WEKO 16544

Nakamura, Eri

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井上, 稔

× 井上, 稔

WEKO 16545

井上, 稔

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Inouye, MInoru

× Inouye, MInoru

WEKO 16546

Inouye, MInoru

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伊藤, 義美

× 伊藤, 義美

WEKO 16547

伊藤, 義美

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Ito, Yoshimi

× Ito, Yoshimi

WEKO 16548

Ito, Yoshimi

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キーワード
主題Scheme Other
主題 小頭症
キーワード
主題Scheme Other
主題 microcephaly
キーワード
主題Scheme Other
主題 蛍光色素
キーワード
主題Scheme Other
主題 DiI
キーワード
主題Scheme Other
主題 発達
キーワード
主題Scheme Other
主題 development
キーワード
主題Scheme Other
主題 神経回路
キーワード
主題Scheme Other
主題 neural circuits
キーワード
主題Scheme Other
主題 海馬
キーワード
主題Scheme Other
主題 hippocampus
抄録
内容記述 The abnormal development of local neural circuits in the hippocampus of infant rats with methylazoxymethanol (MAM)-induced microcephaly (MAM rats) was examined morphologically. MAM-rats were obtained from dams intraperitoneally injected with MAM (20 mg/kg) on the 15th day of gestation. Rat pups at postnatal day 1,3 or 7 were anesthetized and intracardially perfused with 4 % formaldehyde. Small crystals of DiI were inserted into the CA1 of stratum pyramidale of hippocampus slices with a fine glass needle. Additional brain samples were embedded in paraffin, sectioned and stained with cresyl violet. In 1-day-old MAM-rats, althogh cytoarchitecture of the stratum pyramidale stained with cresyl violet compared to that of controls, DiI-labeled pyramidal neurons showed high packing densities with poorly developed dendritic branches. In the age-matched control, many DiI-labeled pyramidal neurons were orderly lined up and they had well-developed dendritic plexus. On day 3 and 7 the developmental abnormality of the local circuits in CA1 became more remarkable in both cresyl violet-stained and DiI-labeled sections. This showed that the abnormality of neural network was more striking when compared with the abnormal arrangement of neuronal somata in the hippocamcus of MAM rats shortly after birth.
内容記述タイプ Abstract
出版者
出版者 名古屋大学情報文化学部・名古屋大学大学院人間情報学研究科
言語
言語 jpn
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/stuis.13.111
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 13411403
書誌情報 情報文化研究

巻 13, p. 111-125, 発行日 2001-03-25
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7776
識別子タイプ HDL
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