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小頭症ラットの海馬神経回路の生後発達異常
https://doi.org/10.18999/stuis.13.111
5450ceaa-dbff-4e37-9179-f743bf83db4a
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-11 | |||||
タイトル | ||||||
タイトル | 小頭症ラットの海馬神経回路の生後発達異常 | |||||
その他のタイトル | ||||||
その他のタイトル | Developmental Abnormalities in Neural Circuits in the Hippocampus of Infant Rats with Methylazoxymethanol-induced Microcephaly | |||||
著者 |
中村, 江里
× 中村, 江里× Nakamura, Eri× 井上, 稔× Inouye, MInoru× 伊藤, 義美× Ito, Yoshimi |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | 小頭症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microcephaly | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 蛍光色素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DiI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 発達 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経回路 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neural circuits | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 海馬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hippocampus | |||||
抄録 | ||||||
内容記述 | The abnormal development of local neural circuits in the hippocampus of infant rats with methylazoxymethanol (MAM)-induced microcephaly (MAM rats) was examined morphologically. MAM-rats were obtained from dams intraperitoneally injected with MAM (20 mg/kg) on the 15th day of gestation. Rat pups at postnatal day 1,3 or 7 were anesthetized and intracardially perfused with 4 % formaldehyde. Small crystals of DiI were inserted into the CA1 of stratum pyramidale of hippocampus slices with a fine glass needle. Additional brain samples were embedded in paraffin, sectioned and stained with cresyl violet. In 1-day-old MAM-rats, althogh cytoarchitecture of the stratum pyramidale stained with cresyl violet compared to that of controls, DiI-labeled pyramidal neurons showed high packing densities with poorly developed dendritic branches. In the age-matched control, many DiI-labeled pyramidal neurons were orderly lined up and they had well-developed dendritic plexus. On day 3 and 7 the developmental abnormality of the local circuits in CA1 became more remarkable in both cresyl violet-stained and DiI-labeled sections. This showed that the abnormality of neural network was more striking when compared with the abnormal arrangement of neuronal somata in the hippocamcus of MAM rats shortly after birth. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | 名古屋大学情報文化学部・名古屋大学大学院人間情報学研究科 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/stuis.13.111 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13411403 | |||||
書誌情報 |
情報文化研究 巻 13, p. 111-125, 発行日 2001-03-25 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7776 | |||||
識別子タイプ | HDL |