@article{oai:nagoya.repo.nii.ac.jp:00006140,
 author = {中村, 江里 and Nakamura, Eri and 井上, 稔 and Inouye, MInoru and 伊藤, 義美 and Ito, Yoshimi},
 journal = {情報文化研究},
 month = {Mar},
 note = {The abnormal development of local neural circuits in the hippocampus of infant rats with methylazoxymethanol (MAM)-induced microcephaly (MAM rats) was examined morphologically. MAM-rats were obtained from dams intraperitoneally injected with MAM (20 mg/kg) on the 15th day of gestation. Rat pups at postnatal day 1,3 or 7 were anesthetized and intracardially perfused with 4 % formaldehyde. Small crystals of DiI were inserted into the CA1 of stratum pyramidale of hippocampus slices with a fine glass needle. Additional brain samples were embedded in paraffin, sectioned and stained with cresyl violet. In 1-day-old MAM-rats, althogh cytoarchitecture of the stratum pyramidale stained with cresyl violet compared to that of controls, DiI-labeled pyramidal neurons showed high packing densities with poorly developed dendritic branches. In the age-matched control, many DiI-labeled pyramidal neurons were orderly lined up and they had well-developed dendritic plexus. On day 3 and 7 the developmental abnormality of the local circuits in CA1 became more remarkable in both cresyl violet-stained and DiI-labeled sections. This showed that the abnormality of neural network was more striking when compared with the abnormal arrangement of neuronal somata in the hippocamcus of MAM rats shortly after birth.},
 pages = {111--125},
 title = {小頭症ラットの海馬神経回路の生後発達異常},
 volume = {13},
 year = {2001}
}