@article{oai:nagoya.repo.nii.ac.jp:00006249, author = {鳥橋, 茂子 and Torihashi, Shigeko}, issue = {10}, journal = {臨牀消化器内科}, month = {}, note = {神経解剖学者カハールが記載したといわれる腸管筋層固有の細胞は現在,カハールの介在細胞(ICC)と一般に呼ばれている.ICCは癌原遺伝子c-kitを発現し,その産物c-Kitレセプター依存性に分化,増殖する.そしてc-kitを指標として形態学的,生理学的研究が進展した.ICCには少なくとも2種類の機能および形態の異なるタイプが存在する.一つは消化管平滑筋に特徴的な律動的自動運動のペースメーカーであり,また他のグループは平滑筋と神経との間に介在して神経からの神経伝達の調節に関与している.ICCはその発生過程でも腸管神経と深く関わり,神経はc-Kitレセプターのリガンドを産生している., Interstitial cells of Cajal (ICC) were named after the famous neuroscientist Cajal SR. Recently it was found that ICC expressed proto-oncogene c-kit, needed for the growth and development of these cell. After that c-kit has become a good tool for both morphological and physiological studies of ICC. There are two types of ICC. One works as a pacemaker for the spontaneous contraction of smooth muscles in the gastrointestinal tract. These cells generate a pacemaker current and propagate to the smooth muscle through gap junctions to raise slow waves, and produce rhythmic contractions. The other ICC group is considered to be the neuro-modulators intercalated between enteric neurons and smooth muscles. These cells amplify nitrinergic and cholinergic neurotransmissions. Those ICC have several receptors of neurotransmitters such as neurokinin 1, somatostatin 2A, etc. In relation to the development of ICC, enteric neurons also show an close relationship to ICC inproducing stem cell factors, a ligand for c-Kit.}, pages = {1371--1377}, title = {腸管平滑筋運動におけるカハールの介在細胞と壁内神経 (特集. Neurogastroenterologyの幕開け)}, volume = {18}, year = {2003} }