@article{oai:nagoya.repo.nii.ac.jp:00007084,
 author = {HARAGUCHI, Hiroki and OHSHIMA, Tomomi and MATSUURA, Hirotaka and HASEGAWA, Takuya},
 issue = {sup},
 journal = {Analytical Sciences},
 month = {},
 note = {Speciation of cisplatin (CDDP; cis-diamminedichloroplatinum(Ⅱ)), anti-cancer drug, in human blood serum has been carried out by surfactant- mediated HPLC/ICP-MS. In the surfactant-mediated HPLC, an ODS (octadesylsilica) column coated with CHAPS (3-[3-cholamidopropyl]-dimethylammonio) propanesulfonic acid), which is a zwitterionic surfactant obtained as a bile acid derivative, was employed as a stationary phase, and ICP-MS was used for detection of 195Pt. Since the present surfactant-mediated stationary phase had the characteristics of rapid separation of large and small molecules with capability of direct sample injection even for blood serum without any pretreatment, CDDP and its complexes with cysteine and albumin in addition to some hydrolysis-type complexes were found in human blood serum., Proceedings of IUPAC International Congress on Analytical Sciences 2001 (ICAS 2001)},
 pages = {i37--i40},
 title = {Speciation of Drugs in Blood Serum by Surfactant-Mediated HPLC/ICP-MS with Direct Sample Injection},
 volume = {17},
 year = {2001}
}