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Roles of noise in single and coupled multiple genetic oscillators
http://hdl.handle.net/2237/8798
http://hdl.handle.net/2237/8798708433b4-13ca-452b-b95a-2268f153b209
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-09-28 | |||||
タイトル | ||||||
タイトル | Roles of noise in single and coupled multiple genetic oscillators | |||||
言語 | en | |||||
著者 |
Yoda, Mitsumasa
× Yoda, Mitsumasa× Ushikubo, Tomohiro× Inoue, Wataru× Sasai, Masaki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | The noisy fluctuation of chemical reactions should profoundly affect the oscillatory dynamics of gene circuit. In this paper a prototypical genetic oscillator, repressilator, is numerically simulated to analyze effects of noise on oscillatory dynamics. The oscillation is coherent when the protein number and the rate of the DNA state alteration are within appropriate ranges, showing the phenomenon of coherence resonance. Stochastic fluctuation not only disturbs the coherent oscillation in a chaotic way but also destabilizes the stationary state to make the oscillation relatively stable. Bursting in translation, which is a source of intense stochastic fluctuation in protein numbers, suppresses the destructive effects of the finite leakage rate of protein production and thus plays a constructive role for the persistent oscillation. When multiple repressilators are coupled to each other, the cooperative interactions among repressilators enhance the coherence in oscillation but the dephasing fluctuation among multiple repressilators induces the amplitude fluctuation in the collective oscillation. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | American Institute of Physics | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1063/1.2539037 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9606 | |||||
書誌情報 |
en : THE JOURNAL OF CHEMICAL PHYSICS 巻 126, 号 11, p. 115101-115101, 発行日 2007-03-21 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/8798 | |||||
識別子タイプ | HDL |