{"created":"2021-03-01T06:14:00.018570+00:00","id":7346,"links":{},"metadata":{"_buckets":{"deposit":"f16a3157-4bfe-4c62-8c31-781ec0a773a8"},"_deposit":{"id":"7346","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7346"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00007346","sets":["643:666:667"]},"author_link":["20344","20345","20346"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"99","bibliographicPageStart":"92","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Cellular and Molecular Life Sciences","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human bystin was identified as a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. Although the trophinin gene is unique to mammals, the bystin gene (BYSL) is conserved across eukaryotes. Recent studies show that bystin plays a key role during the transition from silent trophectoderm to an active trophoblast upon trophinin-mediated cell adhesion. Bystin gene knockout and knockdown experiments demonstrate that bystin is essential for embryonic stem cell survival and trophectoderm development in the mouse. Furthermore, biochemical analysis of bystin in human cancer cells and mouse embryos indicates a function in ribosomal biogenesis, specifically in processing of 18S RNA in the 40S subunit. Strong evidence that BYSL is a target of c-MYC is consistent with bystin’s role in rapid protein synthesis, which is required for actively growing cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/9027"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00018-007-7302-9","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The original publication is available at www.springerlink.com.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1420-9071","subitem_source_identifier_type":"PISSN"}]},"item_10_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FUKUDA, Michiko N","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIYOSHI, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NADANO, Daita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20346","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"CMLS-Bysl.pdf","filesize":[{"value":"996.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CMLS-Bysl.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/7346/files/CMLS-Bysl.pdf"},"version_id":"a8022d24-2313-4134-b88b-f8d9653e5588"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BYSL","subitem_subject_scheme":"Other"},{"subitem_subject":"Enp1","subitem_subject_scheme":"Other"},{"subitem_subject":"ribosome","subitem_subject_scheme":"Other"},{"subitem_subject":"embryo","subitem_subject_scheme":"Other"},{"subitem_subject":"trophoblast","subitem_subject_scheme":"Other"},{"subitem_subject":"placenta","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The role of bystin in embryo implantation and in ribosomal biogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of bystin in embryo implantation and in ribosomal biogenesis","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["667"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-11-21"},"publish_date":"2007-11-21","publish_status":"0","recid":"7346","relation_version_is_last":true,"title":["The role of bystin in embryo implantation and in ribosomal biogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T03:54:30.665207+00:00"}