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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Central administration of glucagon suppresses food intake in chicks

http://hdl.handle.net/2237/9266
http://hdl.handle.net/2237/9266
09db37a9-e5c5-478b-8dc7-28c91a337486
名前 / ファイル ライセンス アクション
S_Hasegawa.pdf S_Hasegawa.pdf (374.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-01-10
タイトル
タイトル Central administration of glucagon suppresses food intake in chicks
言語 en
著者 Honda, Kazuhisa

× Honda, Kazuhisa

WEKO 21318

en Honda, Kazuhisa

Search repository
Kamisoyama, Hiroshi

× Kamisoyama, Hiroshi

WEKO 21319

en Kamisoyama, Hiroshi

Search repository
Saito, Noboru

× Saito, Noboru

WEKO 21320

en Saito, Noboru

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Kurose, Yohei

× Kurose, Yohei

WEKO 21321

en Kurose, Yohei

Search repository
Sugahara, Kunio

× Sugahara, Kunio

WEKO 21322

en Sugahara, Kunio

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Hasegawa, Shin

× Hasegawa, Shin

WEKO 21323

en Hasegawa, Shin

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroscience Letters, [VOL 416, ISSUE 2], 2007.
キーワード
主題Scheme Other
主題 Food intake
キーワード
主題Scheme Other
主題 Chicken
キーワード
主題Scheme Other
主題 Glucagon
キーワード
主題Scheme Other
主題 Hyperglycemia
抄録
内容記述 Food intake in chickens is regulated in a manner similar to that in mammals. Corticotropin-releasing factor (CRF), which increases the plasma corticosterone concentration, plays an important role as a mediator of many appetite-suppressive peptides in the central nervous system in both species. Central administration of glucagon suppresses food intake in rats. However, the anorexigenic action of glucagon in chicks has not yet been identified. In the present study, we investigated the effects of central administration of glucagon on food intake in chicks. In tracerebroventricular administration of glucagon in chicks significantly suppressed food intake and significantly induced hyperglycemia. In contrast, peripheral administration of the same dose of glucagon did not influence food intake and plasma glucose concentration. These results suggest that glucagon functions in chicks as an appetite-suppressive peptide in the central nervous system. Intracerebroventricular administration of glucagon in chicks also significantly increased CRF mRNA expression and plasma corticosterone concentration, suggesting that CRF acts as a downstream molecule for a glucagon-induced appetite-suppressive pathway in chicks. It is likely that the induction of hyperglycemia by central administration of glucagon is involved in its anorexigenic action, because peripheral administration of glucose in chicks suppressed food intake. These results suggest that CRF-and/or hyperglycemia-mediated pathways are involved in the anorexigenic action of glucagon in chicks.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : Neuroscience Letters

巻 416, 号 2, p. 198-201, 発行日 2007-04
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/9266
識別子タイプ HDL
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