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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells

http://hdl.handle.net/2237/9388
http://hdl.handle.net/2237/9388
e3d3d311-1239-4f0f-9c1b-88ab0ebbd4b1
名前 / ファイル ライセンス アクション
DevBiol-DMBS.pdf DevBiol-DMBS.pdf (688.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-02-01
タイトル
タイトル Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells
言語 en
著者 MITONAKA, Tomoaki

× MITONAKA, Tomoaki

WEKO 21786

en MITONAKA, Tomoaki

Search repository
MURAMATSU, Yoshiyuki

× MURAMATSU, Yoshiyuki

WEKO 21787

en MURAMATSU, Yoshiyuki

Search repository
SUGIYAMA, Shin

× SUGIYAMA, Shin

WEKO 21788

en SUGIYAMA, Shin

Search repository
MIZUNO, Tomoaki

× MIZUNO, Tomoaki

WEKO 21789

en MIZUNO, Tomoaki

Search repository
NISHIDA, Yasuyoshi

× NISHIDA, Yasuyoshi

WEKO 21790

en NISHIDA, Yasuyoshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author’s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental biology. v.309, 2007, p.78-86, doi:10.1016/j.ydbio.2007.06.021
キーワード
主題Scheme Other
主題 Myosin II
キーワード
主題Scheme Other
主題 MBS
キーワード
主題Scheme Other
主題 apical-basal polarity
キーワード
主題Scheme Other
主題 motility
キーワード
主題Scheme Other
主題 epithelial morphology
抄録
内容記述 Reorganization of the actin cytoskeleton and contraction of actomyosin play pivotal roles in controlling cell shape changes and motility in epithelial morphogenesis. Dephosphorylation of the myosin regulatory light chain (MRLC) by myosin phosphatase is one of the key events involved. Allelic combinations producing intermediate strength mutants of the Drosophila myosin-binding subunit (DMBS) of myosin phosphatase showed imaginal discs with multilayered disrupted morphologies, and extremely mislocated cells, suggesting that DMBS is required to maintain proper epithelial organization. Clonal analyses revealed that DMBS null mutant cells appear to retract basally and localization of apical junction markers such as DE-cadherin are indetectable in most cells, whereas phosphorylated MRLC and F-actin become heavily concentrated apically, indicating misconfiguration of the apical cytoskeleton. In agreement with these findings, DMBS was found to concentrate at the apical domain suggesting its function is localized. Phenotypes similar to DMBS mutants including increased migration of cells were obtained by overexpressing the constitutive active form of MRLC or Rho-associated kinase signifying that the phenotypes are indeed caused through activation of Myosin II. The requirement of DMBS for the integrity of static epithelial cells in imaginal discs suggests that the regulation of Myosin II by DMBS has a role more general than its previously demonstrated functions in morphogenetic events.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ydbio.2007.06.021
ISSN
収録物識別子タイプ PISSN
収録物識別子 0012-1606
書誌情報 en : Developmental biology

巻 309, p. 78-86, 発行日 2007
フォーマット
application/pdf
著者版フラグ
値 author
URI
識別子 http://hdl.handle.net/2237/9388
識別子タイプ HDL
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