{"created":"2021-03-01T06:14:21.224397+00:00","id":7682,"links":{},"metadata":{"_buckets":{"deposit":"1e4bef12-8d83-4083-848d-c35d131a94e6"},"_deposit":{"id":"7682","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7682"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00007682","sets":["336:695:696"]},"author_link":["21791","21792"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"418","bibliographicPageStart":"411","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Development, Growth & Differentiation","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mi-2, the central component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is known as an SNF2-type ATP-dependent nucleosome remodeling factor. No morphological mutant phenotype of Drosophila Mi-2 (dMi-2) had been reported previously, however, we found that rare escapers develop into adult flies showing an extra bristle phenotype. The dMi-2 enhanced the phenotype of ac^Hw49c, which is a dominant gain-of-function allele of achaete (ac) and produces extra bristles. Consistent with these observations, the ac-expressing proneural clusters were expanded, and extra sensory organ precursors (SOPs) were formed in the dMi-2 mutant wing discs. Immunostaining of polytene chromosome showed that dMi-2 binds to the ac locus, and dMi-2 and acetylated hisotones distribute on polytene chromosomes in a mutually exclusive manner. The chromatin immunoprecipitation assay of the wing imaginal disc also demonstrated a binding of dMi-2 on the ac locus. These results suggest that the Drosophila Mi-2/NuRD complex functions in neuronal differentiation through the repression of proneural gene expression by chromatin remodeling and histone deacetylation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/9393"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/j.1440-169X.2006.00880.x","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMASAKI, Yasutoyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIDA, Yasuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21792","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"DGD-dMi-2.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DGD-dMi-2.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/7682/files/DGD-dMi-2.pdf"},"version_id":"e43be100-20aa-4880-95a8-6cc677df2b0d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NuRD complex","subitem_subject_scheme":"Other"},{"subitem_subject":"chromatin remodeling factor","subitem_subject_scheme":"Other"},{"subitem_subject":"sensory organ development","subitem_subject_scheme":"Other"},{"subitem_subject":"proneural gene","subitem_subject_scheme":"Other"},{"subitem_subject":"macrochaete","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["696"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-02-04"},"publish_date":"2008-02-04","publish_status":"0","recid":"7682","relation_version_is_last":true,"title":["Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T03:46:56.320797+00:00"}