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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 70(1-2)

AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION

https://doi.org/10.18999/nagjms.70.1-2.11
https://doi.org/10.18999/nagjms.70.1-2.11
c7f8992c-95d7-46cd-8eb8-7eca98800762
名前 / ファイル ライセンス アクション
p11-17_Xiaofei.pdf p11-17_Xiaofei.pdf (241.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-04-09
タイトル
タイトル AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION
著者 JI, XIAOFEI

× JI, XIAOFEI

WEKO 22615

JI, XIAOFEI

Search repository
TAKAHASHI, NAGAHIDE

× TAKAHASHI, NAGAHIDE

WEKO 22616

TAKAHASHI, NAGAHIDE

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BRANKO, ALEKSIC

× BRANKO, ALEKSIC

WEKO 22617

BRANKO, ALEKSIC

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ISHIHARA, RYOKO

× ISHIHARA, RYOKO

WEKO 22618

ISHIHARA, RYOKO

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NAGAI, TAKU

× NAGAI, TAKU

WEKO 22619

NAGAI, TAKU

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MOURI, AKIHIRO

× MOURI, AKIHIRO

WEKO 22620

MOURI, AKIHIRO

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SAITO, SHINICHI

× SAITO, SHINICHI

WEKO 22621

SAITO, SHINICHI

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MAENO, NOBUHISA

× MAENO, NOBUHISA

WEKO 22622

MAENO, NOBUHISA

Search repository
INADA, TOSHIYA

× INADA, TOSHIYA

WEKO 22623

INADA, TOSHIYA

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OZAKI, NORIO

× OZAKI, NORIO

WEKO 22624

OZAKI, NORIO

Search repository
キーワード
主題Scheme Other
主題 5-HT3B subunit
キーワード
主題Scheme Other
主題 Polymorphism
キーワード
主題Scheme Other
主題 Treatment-resistant
キーワード
主題Scheme Other
主題 Luciferase assay
キーワード
主題Scheme Other
主題 Schizophrenia
抄録
内容記述 Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p<0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.70.1-2.11
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 00277622
書誌情報 Nagoya journal of medical science

巻 70, 号 1-2, p. 11-17, 発行日 2008-03
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/9647
識別子タイプ HDL
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