{"_buckets": {"deposit": "922e0584-55dc-48af-ba55-fc9444860627"}, "_deposit": {"created_by": 17, "id": "7925", "owners": [17], "pid": {"revision_id": 0, "type": "depid", "value": "7925"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00007925", "sets": []}, "author_link": ["22615", "22616", "22617", "22618", "22619", "22620", "22621", "22622", "22623", "22624"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "17", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "70", "bibliographic_titles": [{"bibliographic_title": "Nagoya journal of medical science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p\u003c0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/9647"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.70.1-2.11", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN（Online）", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, 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[{"nameIdentifier": "22617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHIHARA, RYOKO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAGAI, TAKU", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22619", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MOURI, AKIHIRO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22620", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SAITO, SHINICHI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22621", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MAENO, NOBUHISA", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22622", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "INADA, TOSHIYA", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OZAKI, NORIO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22624", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p11-17_Xiaofei.pdf", "filesize": [{"value": "241.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 241500.0, "url": {"label": "p11-17_Xiaofei.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/7925/files/p11-17_Xiaofei.pdf"}, "version_id": "20978caf-ecfe-41fe-aa49-839bdcf4a48f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "5-HT3B subunit", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Treatment-resistant", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Luciferase assay", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Schizophrenia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "17", "path": ["955"], "permalink_uri": "https://doi.org/10.18999/nagjms.70.1-2.11", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-04-09"}, "publish_date": "2008-04-09", "publish_status": "0", "recid": "7925", "relation": {}, "relation_version_is_last": true, "title": ["AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION"], "weko_shared_id": -1}