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AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION
https://doi.org/10.18999/nagjms.70.1-2.11
https://doi.org/10.18999/nagjms.70.1-2.11c7f8992c-95d7-46cd-8eb8-7eca98800762
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-09 | |||||
タイトル | ||||||
タイトル | AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION | |||||
著者 |
JI, XIAOFEI
× JI, XIAOFEI× TAKAHASHI, NAGAHIDE× BRANKO, ALEKSIC× ISHIHARA, RYOKO× NAGAI, TAKU× MOURI, AKIHIRO× SAITO, SHINICHI× MAENO, NOBUHISA× INADA, TOSHIYA× OZAKI, NORIO |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-HT3B subunit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Treatment-resistant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Luciferase assay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schizophrenia | |||||
抄録 | ||||||
内容記述 | Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p<0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.70.1-2.11 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00277622 | |||||
書誌情報 |
Nagoya journal of medical science 巻 70, 号 1-2, p. 11-17, 発行日 2008-03 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/9647 | |||||
識別子タイプ | HDL |