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AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION
https://doi.org/10.18999/nagjms.70.1-2.11
https://doi.org/10.18999/nagjms.70.1-2.11c7f8992c-95d7-46cd-8eb8-7eca98800762
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
p11-17_Xiaofei.pdf (241.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-09 | |||||
| タイトル | ||||||
| タイトル | AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION | |||||
| 言語 | en | |||||
| 著者 |
JI, XIAOFEI
× JI, XIAOFEI× TAKAHASHI, NAGAHIDE× BRANKO, ALEKSIC× ISHIHARA, RYOKO× NAGAI, TAKU× MOURI, AKIHIRO× SAITO, SHINICHI× MAENO, NOBUHISA× INADA, TOSHIYA× OZAKI, NORIO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 5-HT3B subunit | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Treatment-resistant | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Luciferase assay | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Schizophrenia | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p<0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.70.1-2.11 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya journal of medical science 巻 70, 号 1-2, p. 11-17, 発行日 2008-03 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/9647 | |||||
| 識別子タイプ | HDL | |||||
